A stereochemically well-defined rhodium(III) catalyst for asymmetric transfer hydrogenation of ketones

被引：161
作者：
Matharu, DS
Morris, DJ
Kawamoto, AM
Clarkson, GJ
Wills, M [1 ]
机构：
[1] Univ Warwick, Dept Chem, Asymmetr Catalysis Grp, Coventry CV4 7AL, W Midlands, England
[2] Univ Warwick, Dept Chem, Xray Crystallog Unit, Coventry CV4 7AL, W Midlands, England
来源：
ORGANIC LETTERS | 2005年 / 7卷 / 24期
基金：
英国工程与自然科学研究理事会;
关键词：
D O I：
10.1021/ol052559f
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A rhodium(III) catalyst for asymmetric transfer hydrogenation of ketones has been designed. The incorporation of a tethering group between the diamino group and the cyclopentadienyl unit provides extra stereochemical rigidity. The catalyst is capable of enantioselective reduction of a range of ketones in excellent ee using formic acid/triethylamine as both the solvent and the reducing agent.
引用
收藏
页码：5489 / 5491
页数：3
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