Female XX sex chromosomes increase survival and extend lifespan in aging mice

被引：48

作者：

Davis, Emily J. ^{[1
,2
]}

Lobach, Iryna ^{[3
]}

Dubal, Dena B. ^{[1
,2
]}

机构：

[1] Univ Calif San Francisco, Biomed Sci Grad Program, Dept Neurol, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Weill Inst Neurosci, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA

来源：

AGING CELL | 2019年 / 18卷 / 01期

基金：

美国国家科学基金会;

关键词：

aging; four core genotype; life-span studies; mortality; mouse models; sex differences; sex hormones; COMPLEMENT;

D O I：

10.1111/acel.12871

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Female longevity is observed in humans and much of the animal kingdom, but its causes remain elusive. Using a genetic manipulation that generates XX and XY mice, each with either ovaries or testes, we show that the female XX sex chromosome complement increases survival during aging in male and female mice. In combination with ovaries, it also extends lifespan. Understanding causes of sex-based differences in aging could lead to new pathways to counter age-induced decline in both sexes.

引用

页数：5

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