Voxel-based magnetic resonance imaging study of structural brain changes in patients with idiopathic REM sleep behavior disorder

被引：67

作者：

Hanyu, Haruo ^{[1
]}

Inoue, Yuichi ^{[2
,3
]}

Sakurai, Hirofumi ^{[1
]}

Kanetaka, Hidekazu ^{[1
]}

Nakamura, Masaki ^{[2
]}

Miyamoto, Tomoyuki ^{[4
]}

Sasai, Taeko ^{[2
,3
]}

Iwamoto, Toshihiko ^{[1
]}

机构：

[1] Tokyo Med Univ, Dept Geriatr Med, Shinjuku Ku, Tokyo 1600023, Japan

[2] Japan Somnol Ctr, Neuropsychiatr Res Inst, Tokyo, Japan

[3] Tokyo Med Univ, Dept Somnol, Tokyo, Japan

[4] Dokkyo Med Univ, Sch Med, Ctr Sleep Med, Dept Neurol, Mibu, Tochigi, Japan

来源：

PARKINSONISM & RELATED DISORDERS | 2012年 / 18卷 / 02期

关键词：

REM sleep behavior disorder; Synucleinopathy; MRI; Voxel-based morphometry; OLFACTORY DYSFUNCTION; STEM;

D O I：

10.1016/j.parkreldis.2011.08.023

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Purpose: Rapid eye movement (REM) sleep behavior disorder (RBD) is considered to result from dysfunction of the brain stem structures that regulate REM sleep. In this study, we investigated structural brain changes using magnetic resonance imaging (MRI) in patients with idiopathic RBD (iRBD) to determine structural brain alterations associated with the disorder. Methods: Voxel-based MRI morphometry was applied to 20 patients with iRBD and findings were compared with those from 18 age-matched controls. Results: Compared with the controls, the patients with iRBD had significant gray matter volume reduction in the anterior lobes of the right and left cerebellum, tegmental portion of the pons, and left parahippocampal gyrus. Conclusion: The present study provides in vivo evidence suggesting that structural lesions of the brain stem are responsible for the occurrence of iRBD. In addition, the pattern of gray matter loss is consistent with morphological changes commonly observed in patients with Lewy body disease and multiple system atrophy, indicating that iRBD can share a common morphological abnormality with alphasynucleinopathies. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：136 / 139

页数：4

共 30 条

[1]

[Anonymous], 1992, Jpn. J. Geriatr. Psychiatry

[2]

[Anonymous], 2005, Diagnostic and coding manual, P148

[3] Pathophysiology of REM sleep behaviour disorder and relevance to neurodegenerative disease [J].

Boeve, B. F. ;

Silber, M. H. ;

Saper, C. B. ;

Ferman, T. J. ;

Dickson, D. W. ;

Parisi, J. E. ;

Benarroch, E. E. ;

Ahlskog, J. E. ;

Smith, G. E. ;

Caselli, R. C. ;

Tippman-Peikert, M. ;

Olson, E. J. ;

Lin, S. -C. ;

Young, T. ;

Wszolek, Z. ;

Schenck, C. H. ;

Mahowald, M. W. ;

Castillo, P. R. ;

Del Tredici, K. ;

Braak, H. .

BRAIN, 2007, 130 :2770-2788

[4] Evolving knowledge of sex differences in brain structure, function, and chemistry [J].

Cosgrove, Kelly P. ;

Mazure, Carolyn M. ;

Staley, Julie K. .

BIOLOGICAL PSYCHIATRY, 2007, 62 (08) :847-855

[5] The FAB - A frontal assessment battery at bedside [J].

Dubois, B ;

Slachevsky, A ;

Litvan, I ;

Pillon, B .

NEUROLOGY, 2000, 55 (11) :1621-1626

[6] Reduced striatal dopamine transporters in idiopathic rapid eye movement sleep behaviour disorder - Comparison with Parkinson's disease and controls [J].

Eisensehr, I ;

Linke, R ;

Noachtar, S ;

Schwarz, J ;

Gildehaus, FJ ;

Tatsch, K .

BRAIN, 2000, 123 :1155-1160

[7] Olfactory deficit in idiopathic rapid eye movements sleep behavior disorder [J].

Fantini, Maria Livia ;

Postuma, Ronald B. ;

Montplaisir, Jacques ;

Ferini-Strambi, Luigi .

BRAIN RESEARCH BULLETIN, 2006, 70 (4-6) :386-390

[8] Neuropsychological assessment in idiopathic REM sleep behavior disorder (RBD) - Does the idiopathic form of RBD really exist? [J].

Ferini-Strambi, L ;

Di Gioia, MR ;

Castronovo, V ;

Oldani, A ;

Zucconi, M ;

Cappa, SF .

NEUROLOGY, 2004, 62 (01) :41-45

[9] MINI-MENTAL STATE - PRACTICAL METHOD FOR GRADING COGNITIVE STATE OF PATIENTS FOR CLINICIAN [J].

FOLSTEIN, MF ;

FOLSTEIN, SE ;

MCHUGH, PR .

JOURNAL OF PSYCHIATRIC RESEARCH, 1975, 12 (03) :189-198

[10] A voxel-based morphometric study of ageing in 465 normal adult human brains [J].

Good, CD ;

Johnsrude, IS ;

Ashburner, J ;

Henson, RNA ;

Friston, KJ ;

Frackowiak, RSJ .

NEUROIMAGE, 2001, 14 (01) :21-36

← 1 2 3 →