Synthesis and complementary self-association of novel lipophilic π-conjugated nucleoside oligomers

被引：37

作者：

Camacho-Garcia, J. ^{[1
]}

Montoro-Garcia, C. ^{[1
]}

Lopez-Perez, A. M. ^{[1
]}

Bilbao, N. ^{[1
]}

Romero-Perez, S. ^{[1
]}

Gonzalez-Rodriguez, D. ^{[1
]}

机构：

[1] Univ Autonoma Madrid, Dept Quim Organ, Nanostruct Mol Syst & Mat Grp, E-28049 Madrid, Spain

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2015年 / 13卷 / 15期

基金：

欧洲研究理事会;

关键词：

HYDROGEN-BOND; COMPLEXES; GUANOSINE; DERIVATIVES; RECOGNITION; NUCLEOBASES; PURINE; DNA;

D O I：

10.1039/c5ob00098j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of lipophilic nucleosides comprising natural and non-natural bases that are pi-conjugated to a short oligophenylene-ethynylene fragment has been synthesized. These bases comprise guanosine, isoguanosine, and 2-aminoadenosine as purine heterocycles, and cytidine, isocytosine and uridine as complementary pyrimidine bases. The hydrogen-bonding dimerization and association processes between complementary bases were also studied by H-1 NMR and absorption spectroscopy in order to obtain the relevant association constants.

引用

页码：4506 / 4513

页数：8

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