Characterization of curcumin-PVP solid dispersion obtained by spray drying

被引：267

作者：

Paradkar, A ^{[1
]}

Ambike, AA ^{[1
]}

Jadhav, BK ^{[1
]}

Mahadik, KR ^{[1
]}

机构：

[1] Bharati Vidyapeeth deemed Univ, Poona Coll Pharm, Dept Pharmaceut, Pune 411038, Maharashtra, India

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2004年 / 271卷 / 1-2期

关键词：

curcumin; PVP; spray drying; solid dispersion; dissolution enhancement;

D O I：

10.1016/j.ijpharm.2003.11.014

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Curcumin, a naturally occurring highly lipophilic molecule has wide range of pharmacological activities. However, its limited aqueous solubility and degradation at alkaline pH restricts its bioavailability. Solid dispersions of curcumin in different ratios with PVP were prepared by spray drying. Physical characterization by SEM, IR, DSC, and XRPD studies, in comparison with corresponding physical mixtures revealed the changes in solid state during the formation of dispersion and justified the formation of high-energy amorphous phase. Dissolution studies of curcumin and its physical mixtures in 0.1 N HCl showed negligible release even after 90 min. Whereas, solid dispersions showed complete dissolution within 30 min. This may aid in improving bioavailability and dose reduction of the drug. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：281 / 286

页数：6

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