Synthesis of fused 4,5-disubstituted indole ring systems by intramolecular Friedel-Crafts acylation of 4-substituted indoles

被引：36

作者：

Fillion, Eric ^{[1
]}

Dumas, Aaron M. ^{[1
]}

机构：

[1] Univ Waterloo, Dept Chem, Waterloo, ON N2L 3G1, Canada

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2008年 / 73卷 / 07期

关键词：

D O I：

10.1021/jo702591p

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

4-Substituted indoles containing a variety of electrophiles and N-substituents undergo Friedel-Crafts acylation to give exclusively the products of cyclization at the 5-position of indole. These indanones and tetralones have been scarcely prepared and are subunits in natural products and analogues of potential biological significance.

引用

页码：2920 / 2923

页数：4

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