Murine leukemia virus-based Tat-inducible long terminal repeat replacement vectors: A new system for anti-human immunodeficiency virus gene therapy

被引：22

作者：

Cannon, PM ^{[1
]}

Kim, N ^{[1
]}

Kingsman, SM ^{[1
]}

Kingsman, AJ ^{[1
]}

机构：

[1] UNIV OXFORD,DEPT BIOCHEM,RETROVIRUS MOL BIOL GRP,OXFORD OX1 3QU,ENGLAND

来源：

JOURNAL OF VIROLOGY | 1996年 / 70卷 / 11期

关键词：

D O I：

10.1128/JVI.70.11.8234-8240.1996

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We have constructed new murine leukemia virus (MLV)-based vectors (TIN vectors) which, following integration, contain human immunodeficiency virus (HIV) type I U3 and R sequences in place of the MLV U3 and R regions. This provides, for the first time, single transcriptional unit retroviral vectors under the control of Tat. TIN vectors have several advantages for anti-HIV gene therapy applications.

引用

页码：8234 / 8240

页数：7

共 56 条

[1] INTERNAL INITIATION OF TRANSLATION IN RETROVIRAL VECTORS CARRYING PICORNAVIRUS-5' NONTRANSLATED REGIONS [J].

ADAM, MA ;

RAMESH, N ;

MILLER, AD ;

OSBORNE, WRA .

JOURNAL OF VIROLOGY, 1991, 65 (09) :4985-4990

[2] SYNTHESIS OF A GENE FOR THE HIV TRANSACTIVATOR PROTEIN TAT BY A NOVEL SINGLE STRANDED APPROACH INVOLVING INVIVO GAP REPAIR [J].

ADAMS, SE ;

JOHNSON, ID ;

BRADDOCK, M ;

KINGSMAN, AJ ;

KINGSMAN, SM ;

EDWARDS, RM .

NUCLEIC ACIDS RESEARCH, 1988, 16 (10) :4287-4298

[3] TRANS-ACTIVATOR GENE OF HUMAN T-LYMPHOTROPIC VIRUS TYPE-III (HTLV-III) [J].

ARYA, SK ;

GUO, C ;

JOSEPHS, SF ;

WONGSTAAL, F .

SCIENCE, 1985, 229 (4708) :69-73

[4] COMPARISON OF TRANSDOMINANT INHIBITORY MUTANT HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 GENES EXPRESSED BY RETROVIRAL VECTORS IN HUMAN T-LYMPHOCYTES [J].

BAHNER, I ;

ZHOU, C ;

YU, XJ ;

HAO, QL ;

GUATELLI, JC ;

KOHN, DB .

JOURNAL OF VIROLOGY, 1993, 67 (06) :3199-3207

[5] FUNCTIONAL ROLES FOR THE TATA PROMOTER AND ENHANCERS IN BASAL AND TAT-INDUCED EXPRESSION OF THE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 LONG TERMINAL REPEAT [J].

BERKHOUT, B ;

JEANG, KT .

JOURNAL OF VIROLOGY, 1992, 66 (01) :139-149

[6] INHIBITION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REPLICATION IN HUMAN T-CELLS BY RETROVIRAL-MEDIATED GENE-TRANSFER OF A DOMINANT-NEGATIVE REV TRANSACTIVATOR [J].

BEVEC, D ;

DOBROVNIK, M ;

HAUBER, J ;

BOHNLEIN, E .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (20) :9870-9874

[7] COMPARISON OF EXPRESSION IN HEMATOPOIETIC-CELLS BY RETROVIRAL VECTORS CARRYING 2 GENES [J].

BOWTELL, DDL ;

CORY, S ;

JOHNSON, GR ;

GONDA, TJ .

JOURNAL OF VIROLOGY, 1988, 62 (07) :2464-2473

[8] A NUCLEAR TRANSLATIONAL BLOCK IMPOSED BY THE HIV-1 U3 REGION IS RELIEVED BY THE TAT-TAR INTERACTION [J].

BRADDOCK, M ;

THORBURN, AM ;

CHAMBERS, A ;

ELLIOTT, GD ;

ANDERSON, GJ ;

KINGSMAN, AJ ;

KINGSMAN, SM .

CELL, 1990, 62 (06) :1123-1133

[9] SPECIFIC ABLATION OF HUMAN-IMMUNODEFICIENCY-VIRUS TAT-EXPRESSING CELLS BY CONDITIONALLY TOXIC RETROVIRUSES [J].

BRADY, HJM ;

MILES, CG ;

PENNINGTON, DJ ;

DZIERZAK, EA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (01) :365-369

[10] SEQUENCE REQUIREMENTS FOR INTEGRATION OF MOLONEY MURINE LEUKEMIA-VIRUS DNA INVITRO [J].

BUSHMAN, FD ;

CRAIGIE, R .

JOURNAL OF VIROLOGY, 1990, 64 (11) :5645-5648

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