Atrial Septal Aneurysm, Shunt Size, and Recurrent Stroke Risk in Patients With Patent Foramen Ovale

被引:70
作者
Turc, Guillaume [1 ,2 ]
Lee, Jong-Young [3 ]
Brochet, Eric [4 ,5 ]
Kim, Jong S. [6 ]
Song, Jae-Kwan [7 ]
Mas, Jean-Louis [1 ,2 ]
机构
[1] Univ Paris, INSERM, U1266, GHU Paris Psychiat & Neurosci,Dept Neurol, Paris, France
[2] FHU Neurovasc, Paris, France
[3] Sungkyunkwan Univ, Sch Med, Kangbuk Samsung Hosp, Div Cardiol,Dept Internal Med, Seoul, South Korea
[4] Univ Paris Diderot, Hop Bichat, AP HP, Dept Cardiol, Paris, France
[5] INSERM, U1148, Paris, France
[6] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Neurol, Seoul, South Korea
[7] Univ Ulsan, Coll Med, Asan Med Ctr, Div Cardiol, 88 Olymp Ro 43 Gil, Seoul 05505, South Korea
关键词
atrial septal aneurysm; large shunt; patent foramen ovale; stroke; TO-LEFT SHUNT; TRANSIENT ISCHEMIC ATTACK; CRYPTOGENIC STROKE; CEREBROVASCULAR EVENTS; CLOSURE; ECHOCARDIOGRAPHY; THERAPY;
D O I
10.1016/j.jacc.2020.02.068
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
BACKGROUND In patients with patent foramen ovate (PFO)-associated stroke, the presence of large shunt or atrial septat aneurysm (ASA) has been suggested to convey a high risk of stroke recurrence. OBJECTIVES The purpose of this study was to assess the respective influence of PFO size and ASA status on stroke recurrence under medical therapy in patients with recent PFO-associated stroke without alternative cause. METHODS The authors pooled individual patient data from 2 prospective observational studies and the medical arms of 2 randomized trials, in which shunt size and ASA status was assessed by independent reading of echocardiographic images. Associations between PFO anatomical features and recurrent ischemic stroke were assessed by mixed effects Cox models. RESULTS Of 898 patients (mean age 45.3 years), 178 (19.8%) had ASA with large PFO, 71 (7.9%) ASA with nonlarge PFO, 397 (44.2%) large PFO without ASA, and 252 (28.1%) nonlarge PFO without ASA. Over a median follow-up of 3.8 years (interquartite range: 2.6 to 5.5 years), 47 (5.2%) patients experienced a recurrent stroke. There was a heterogeneity across studies for the association between PFO size and stroke recurrence (P-interaction = 0.01). In a model accounting for age, hypertension, antithrombotic therapy, and PFO anatomy, ASA was independently associated with recurrent stroke (adjusted hazard ratio: 3.27; 95% confidence interval: 1.82 to 5.86; p < 0.0001), whereas large PFO was not (average adjusted hazard ratio across studies: 1.43; 95% confidence interval: 0.50 to 4.03; p 0.50). CONCLUSIONS In patients with PFO-associated stroke, ASA is a more important predictor of recurrent stroke than shunt size. These results can help to better identify those patients with a high risk of stroke recurrence under medical therapy who may derive the most benefit from PFO closure. (C) 2020 by the American College of Cardiology Foundation.
引用
收藏
页码:2312 / 2320
页数:9
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