Targeting Innate and Adaptive Immune Responses to Cure Chronic HBV Infection

被引：141

作者：

Gehring, Adam J. ^{[1
,2
,3
]}

Protzer, Ulrike ^{[4
,5
]}

机构：

[1] Univ Hlth Network, Toronto Ctr Liver Dis, Toronto, ON, Canada

[2] Univ Hlth Network, Toronto Gen Hosp, Res Inst, Toronto, ON, Canada

[3] Univ Toronto, Dept Immunol, Toronto, ON, Canada

[4] Tech Univ Munich, Inst Virol, Helmholtz Zentrum Munchen, Munich, Germany

[5] German Ctr Infect Res DZIF, Munich Partnersite, Munich, Germany

来源：

GASTROENTEROLOGY | 2019年 / 156卷 / 02期

基金：

欧盟地平线“2020”;

关键词：

Drug; HBsAg; Vaccine; Inflammation; HEPATITIS-B-VIRUS; CD8(+) T-CELLS; ADOPTIVE TRANSFER; VIRAL-HEPATITIS; SURFACE-ANTIGEN; HEPATOCELLULAR-CARCINOMA; PROGRAMMED DEATH-1; LIVER; REPLICATION; HEPATOCYTES;

D O I：

10.1053/j.gastro.2018.10.032

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Fewer than 1% of chronic hepatitis B virus infections per year are cured with antiviral treatment. This creates a need for long-term treatment, which poses challenges for patients and health systems. Because cure is accompanied by recovery of antiviral immunity, a combination of direct-acting antiviral agents and immunotherapy are likely to be required. Extensive efforts have been made to identify determinants of the failed immune response to hepatitis B virus in patients with chronic infection. We review mechanisms of immune dysfunction in patients with chronic hepatitis B virus infection, immunotherapy strategies in development, and the challenges associated with successful implementation of immunotherapy.

引用

页码：325 / 337

页数：13

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