Serum placental growth factor and fms-like tyrosine kinase 1 during first trimester in Chinese women with pre-eclampsia - a case-control study

Methods. aEuro integral This is a matched case--control study using stored serum samples collected from non-smoking Chinese women with singleton pregnancies who underwent first trimester screening for aneuploidy. Each case that developed PE was matched with a control whose maternal age, weight, gestational age and date of blood collection were within aEuroS +/-+/- 2 years, aEuroS +/-+/- 5 kg, aEuroS +/-+/- 1 day, and aEuroS +/-+/- 2 weeks of the index case, respectively. Non-parametric paired test was used to compare the PlGF and sFlt-1 levels. PlGF and sFlt-1 were transformed to their equivalent multiple of the median (MoM) using the matched control as the expected median value. The 95%% confidence interval (CI) of the estimated median PlGF and sFlt-1 MoM in those with PE was determined. Results. aEuro integral The median PlGF level in the 27 study cases with PE was lower than that of the matched controls (42.9 pg/ml versus 59.8 pg/ml; p aEuroS== aEuroS0.001). The median PIGF MoM was 0.71 (95%% CI 0.63--0.92). There was no statistically significant difference in sFlt-1 levels between those with PE and their matched control (p aEuroS== aEuroS0.648). The median sFlt-1 MoM was 1.01 (95%% CI 0.65--1.3). Conclusions. aEuro integral Women who developed PE had lower serum PlGF levels but normal sFlt-1 levels in the first trimester.