Efficient and copper-free Sonogashira cross-coupling reaction catalyzed by Pd(OAc)2/pyrimidines catalytic system

被引：68

作者：

Li, JH ^{[1
]}

Zhang, XD ^{[1
]}

Xie, YX ^{[1
]}

机构：

[1] Hunan Normal Univ, Coll Chem & Chem Engn, Key Lab Chem Biol & Tradit Cinese Med Res, Changsha 410081, Peoples R China

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2005年 / 2005卷 / 20期

关键词：

palladium; cross-coupling reaction; homogeneous catalysis;

D O I：

10.1002/ejoc.200500519

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and copper-free catalyst system for Sonogashira cross-coupling reaction is presented. In the presence of 3 mol-% of Pd(OAC)(2) and 6 mol-% of 2-aminopyrimidine-4,6-diol, various aryl iodides and bromides can be coupled smoothly with terminal alkynes to afford the corresponding coupled alkynes in moderate to excellent yields under mild conditions. (c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005.

引用

页码：4256 / 4259

页数：4

共 46 条

[31] Palladium complexes with tridentate pincer bis-carbene Ligands as efficient catalysts for C-C coupling [J].