Trastuzumab resistance: all roads lead to SRC

被引:24
作者
Muthuswamy, Senthil K. [1 ,2 ]
机构
[1] Univ Toronto, Ontario Canc Inst, Campbell Family Breast Canc Res Inst, Toronto, ON, Canada
[2] Cold Spring Harbor, Cold Spring Harbor Lab, New York, NY USA
关键词
METASTATIC BREAST-CANCER; MONOCLONAL-ANTIBODY; PTEN; PLUS;
D O I
10.1038/nm0411-416
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
[No abstract available]
引用
收藏
页码:416 / 418
页数:4
相关论文
共 15 条
[1]   Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth [J].
Agus, DB ;
Akita, RW ;
Fox, WD ;
Lewis, GD ;
Higgins, B ;
Pisacane, PI ;
Lofgren, JA ;
Tindell, C ;
Evans, DP ;
Maiese, K ;
Scher, HI ;
Sliwkowski, MX .
CANCER CELL, 2002, 2 (02) :127-137
[2]   Phase I Study of Everolimus Plus Weekly Paclitaxel and Trastuzumab in Patients With Metastatic Breast Cancer Pretreated With Trastuzumab [J].
Andre, Fabrice ;
Campone, Mario ;
O'Regan, Ruth ;
Manlius, Corinne ;
Massacesi, Cristian ;
Sahmoud, Tarek ;
Mukhopadhyay, Pabak ;
Soria, Jean-Charles ;
Naughton, Michael ;
Hurvitz, Sara A. .
JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (34) :5110-5115
[3]   Phase II study of weekly intravenous recombinant humanized Anti-p185(HER2) monoclonal antibody in patients with HER2/neu-overexpressing metastatic breast [J].
Baselga, J ;
Tripathy, D ;
Mendelsohn, J ;
Baughman, S ;
Benz, CC ;
Dantis, L ;
Sklarin, NT ;
Seidman, AD ;
Hudis, CA ;
Moore, J ;
Rosen, PP ;
Twaddell, T ;
Henderson, IC ;
Norton, L .
JOURNAL OF CLINICAL ONCOLOGY, 1996, 14 (03) :737-744
[4]   Randomized Study of Lapatinib Alone or in Combination With Trastuzumab in Women With ErbB2-Positive, Trastuzumab-Refractory Metastatic Breast Cancer [J].
Blackwell, Kimberly L. ;
Burstein, Harold J. ;
Storniolo, Anna Maria ;
Rugo, Hope ;
Sledge, George ;
Koehler, Maria ;
Ellis, Catherine ;
Casey, Michelle ;
Vukelja, Svetislava ;
Bischoff, Joachim ;
Baselga, Jose ;
O'Shaughnessy, Joyce .
JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (07) :1124-1130
[5]   Neratinib, an Irreversible ErbB Receptor Tyrosine Kinase Inhibitor, in Patients With Advanced ErbB2-Positive Breast Cancer [J].
Burstein, Harold J. ;
Sun, Yan ;
Dirix, Luc Y. ;
Jiang, Zefei ;
Paridaens, Robert ;
Tan, Antoinette R. ;
Awada, Ahmad ;
Ranade, Anantbhushan ;
Jiao, Shunchang ;
Schwartz, Gary ;
Abbas, Richat ;
Powell, Christine ;
Turnbull, Kathleen ;
Vermette, Jennifer ;
Zacharchuk, Charles ;
Badwe, Rajendra .
JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (08) :1301-1307
[6]  
GARRETT JT, 2011, CANCER BIOL THER, V11, P15045
[7]   Trastuzumab Has Preferential Activity against Breast Cancers Driven by HER2 Homodimers [J].
Ghosh, Ritwik ;
Narasanna, Archana ;
Wang, Shizhen Emily ;
Liu, Shuying ;
Chakrabarty, Anindita ;
Balko, Justin M. ;
Gonzalez-Angulo, Ana Maria ;
Mills, Gordon B. ;
Penuel, Elicia ;
Winslow, John ;
Sperinde, Jeff ;
Dua, Rajiv ;
Pidaparthi, Sailaja ;
Mukherjee, Ali ;
Leitzel, Kim ;
Kostler, Wolfgang J. ;
Lipton, Allan ;
Bates, Michael ;
Arteaga, Carlos L. .
CANCER RESEARCH, 2011, 71 (05) :1871-1882
[8]   Drug therapy: Trastuzumab - Mechanism of action and use in clinical practice [J].
Hudis, Clifford A. .
NEW ENGLAND JOURNAL OF MEDICINE, 2007, 357 (01) :39-51
[9]   Src family protein-tyrosine kinases alter the function of PTEN to regulate phosphatidylinositol 3-kinase/AKT cascades [J].
Lu, YL ;
Yu, QH ;
Liu, JH ;
Zhang, JY ;
Wang, HW ;
Koul, D ;
McMurray, JS ;
Fang, XJ ;
Yung, WKA ;
Siminovitch, KA ;
Mills, GB .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (41) :40057-40066
[10]   Advances in Targeting Src in the Treatment of Breast Cancer and Other Solid Malignancies [J].
Mayer, Erica L. ;
Krop, Ian E. .
CLINICAL CANCER RESEARCH, 2010, 16 (14) :3526-3532