The histamine H4 receptor as a new therapeutic target for inflammation

被引：210
作者：
de Esch, IJP
Thurmond, RL
Jongejan, A
Leurs, R
机构：
[1] Vrije Univ Amsterdam, Leiden Amsterdam Ctr Drug Res, Dept Med Chem, NL-1081 HV Amsterdam, Netherlands
[2] Johnson & Johnson Pharmaceut Res & Dev LLC, San Diego, CA 92121 USA
来源：
TRENDS IN PHARMACOLOGICAL SCIENCES | 2005年 / 26卷 / 09期
关键词：
D O I：
10.1016/j.tips.2005.07.002
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Following the sequencing of the human genome, data-mining efforts have revealed the existence of a new histamine receptor that is expressed at high levels in mast cells and leukocytes. The histamine H-4 receptor has a distinct pharmacological profile and the first compounds that act selectively on the H-4 receptor have been developed. Initial experiments in vivo with H-4 receptor antagonists indicate a role for the H-4 receptor in inflammatory conditions.
引用
收藏
页码：462 / 469
页数：8
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