Chitosan Nanoparticles: A Versatile Platform for Biomedical Applications

被引：87

作者：

Bashir, Showkeen Muzamil ^{[1
]}

Rather, Gulzar Ahmed ^{[2
]}

Patricio, Ana ^{[3
,4
]}

Haq, Zulfiqar ^{[5
]}

Sheikh, Amir Amin ^{[6
]}

Shah, Mohd Zahoor ul Haq ^{[7
]}

Singh, Hemant ^{[8
]}

Khan, Azmat Alam ^{[5
]}

Imtiyaz, Sofi ^{[1
]}

Ahmad, Sheikh Bilal ^{[1
]}

Nabi, Showket ^{[9
]}

Rakhshan, Rabia ^{[1
]}

Hassan, Saqib ^{[10
]}

Fonte, Pedro ^{[3
,4
,11
,12
]}

机构：

[1] Shuhama Alusteng, Div Vet Biochem, Mol Biol Lab, Fac Vet Sci & Anim Husb, Srinagar 190006, India

[2] Sathyabama Inst Sci & Technol Deemed Univ, Dept Biomed Engn, Chennai 600119, Tamil Nadu, India

[3] Univ Lisbon, iBB Inst Bioengn & Biosci, Inst Super Tecn, Dept Bioengn, P-1049001 Lisbon, Portugal

[4] Univ Lisbon, Inst Super Tecn, Associate Lab I4HB Inst Hlth & Bioecon, Av Rovisco Pais, P-1049001 Lisbon, Portugal

[5] Div LPM, ICAR Poultry Seed Project, Skuast K 132001, India

[6] Int Inst Vet Educ & Res IIVER, Rohtak 124001, Haryana, India

[7] Barkatullah Univ, Dept Biosci, Lab Endocrinol, Bhopal 462026, India

[8] Indian Inst Technol, Dept Polymer & Proc Engn, Roorkee 247667, Uttar Pradesh, India

[9] Shuhama Alusteng, Dept Clin Vet Med Eth & Jurisprudence, Large Anim Diagnost Lab, Fac Vet Sci & Anim Husb, Srinagar 190006, India

[10] Pondicherry Univ, Sch Life Sci, Dept Microbiol, Pondicherry 605014, India

[11] Univ Algarve, Ctr Marine Sci CCMAR, Gambelas Campus, P-8005139 Faro, Portugal

[12] Univ Algarve, Fac Sci & Technol, Dept Chem & Pharm, Gambelas Campus, P-8005139 Faro, Portugal

来源：

MATERIALS | 2022年 / 15卷 / 19期

关键词：

drug delivery; nanocarrier; target therapy; chemotherapy; gene therapy; tissue engineering; CROSS-LINKED CHITOSAN; SOLVENT DIFFUSION METHOD; DRUG-DELIVERY; ANTIBACTERIAL ACTIVITY; MOLECULAR-WEIGHT; IN-VITRO; ANTIMICROBIAL ACTIVITY; COMPOSITE SCAFFOLDS; LIPID NANOPARTICLES; OXIDE NANOPARTICLES;

D O I：

10.3390/ma15196521

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Chitosan is a biodegradable and biocompatible natural polymer that has been extensively explored in recent decades. The Food and Drug Administration has approved chitosan for wound treatment and nutritional use. Furthermore, chitosan has paved the way for advancements in different biomedical applications including as a nanocarrier and tissue-engineering scaffold. Its antibacterial, antioxidant, and haemostatic properties make it an excellent option for wound dressings. Because of its hydrophilic nature, chitosan is an ideal starting material for biocompatible and biodegradable hydrogels. To suit specific application demands, chitosan can be combined with fillers, such as hydroxyapatite, to modify the mechanical characteristics of pH-sensitive hydrogels. Furthermore, the cationic characteristics of chitosan have made it a popular choice for gene delivery and cancer therapy. Thus, the use of chitosan nanoparticles in developing novel drug delivery systems has received special attention. This review aims to provide an overview of chitosan-based nanoparticles, focusing on their versatile properties and different applications in biomedical sciences and engineering.

引用

页数：28

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