The microbiome in pancreatic diseases: Recent advances and future perspectives

被引：27

作者：

Ammer-Herrmenau, Christoph ^{[1
]}

Pfisterer, Nina ^{[1
]}

Weingarten, Mark F. J. ^{[1
]}

Neesse, Albrecht ^{[1
]}

机构：

[1] Univ Med Ctr Goettingen, Dept Gastroenterol Gastrointestinal Oncol & Endoc, Gottingen, Germany

来源：

UNITED EUROPEAN GASTROENTEROLOGY JOURNAL | 2020年 / 8卷 / 08期

关键词：

Pancreatic cancer; pancreatitis; microbiome; 16S rRNA sequencing; metagenomic sequencing; ACUTE NECROTIZING PANCREATITIS; TUMOR MICROBIOME; ORAL MICROBIOTA; CANCER; METAANALYSIS; DIVERSITY; BACTERIA;

D O I：

10.1177/2050640620944720

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The human microbiota exerts multiple physiological functions such as the regulation of metabolic and inflammatory processes. High-throughput sequencing techniques such as next-generation sequencing have become widely available in preclinical and clinical settings and have exponentially increased our knowledge about the microbiome and its interaction with host cells and organisms. There is now emerging evidence that microorganisms also contribute to inflammatory and neoplastic diseases of the pancreas. This review summarizes current clinical and translational microbiome studies in acute and chronic pancreatitis as well as pancreatic cancer and provides evidence that the microbiome has a high potential for biomarker discovery. Furthermore, the intestinal and pancreas-specific microbiome may also become an integrative part of diagnostic and therapeutic approaches of pancreatic diseases in the near future.

引用

页码：878 / 885

页数：8

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