Different immune cells mediate mechanical pain hypersensitivity in male and female mice

被引：980

作者：

Sorge, Robert E. ^{[1
,2
]}

Mapplebeck, Josiane C. S. ^{[1
,3
,4
,5
]}

Rosen, Sarah ^{[1
]}

Beggs, Simon ^{[3
,4
,5
]}

Taves, Sarah ^{[6
]}

Alexander, Jessica K. ^{[3
,4
,5
]}

Martin, Loren J. ^{[1
]}

Austin, Jean-Sebastien ^{[1
]}

Sotocinal, Susana G. ^{[1
]}

Chen, Di ^{[1
]}

Yang, Mu ^{[7
]}

Shi, Xiang Qun ^{[7
]}

Huang, Hao ^{[7
]}

Pillon, Nicolas J. ^{[8
]}

Bilan, Philip J. ^{[8
]}

Tu, YuShan ^{[3
]}

Klip, Amira ^{[8
]}

Ji, Ru-Rong ^{[6
]}

Zhang, Ji ^{[7
,9
]}

Salter, Michael W. ^{[3
,5
]}

Mogil, Jeffrey S. ^{[1
,9
]}

机构：

[1] McGill Univ, Dept Psychol, Montreal, PQ, Canada

[2] Univ Alabama Birmingham, Dept Psychol, Birmingham, AL 35294 USA

[3] Hosp Sick Children, Program Neurosci & Mental Hlth, Toronto, ON M5G 1X8, Canada

[4] Univ Toronto, Dept Physiol, Toronto, ON, Canada

[5] Univ Toronto, Ctr Study Pain, Toronto, ON, Canada

[6] Duke Univ, Med Ctr, Dept Anesthesiol, Durham, NC 27710 USA

[7] McGill Univ, Fac Dent, Montreal, PQ, Canada

[8] Hosp Sick Children, Cell Biol Program, Toronto, ON M5G 1X8, Canada

[9] McGill Univ, Alan Edwards Ctr Res Pain, Montreal, PQ, Canada

来源：

NATURE NEUROSCIENCE | 2015年 / 18卷 / 08期

基金：

美国国家卫生研究院; 加拿大健康研究院;

关键词：

SPINAL-CORD; TACTILE ALLODYNIA; NEUROPATHIC PAIN; SEX-DIFFERENCES; MICROGLIA; ANALGESIA; RAT; TRANSECTION; STRESS; MOUSE;

D O I：

10.1038/nn.4053

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A large and rapidly increasing body of evidence indicates that microglia-to-neuron signaling is essential for chronic pain hypersensitivity. Using multiple approaches, we found that microglia are not required for mechanical pain hypersensitivity in female mice; female mice achieved similar levels of pain hypersensitivity using adaptive immune cells, likely T lymphocytes. This sexual dimorphism suggests that male mice cannot be used as proxies for females in pain research.

引用

页码：1081 / +

页数：5

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