Antiangiogenic Effect of Chamigrane Endoperoxides from a Thai Mangrove-Derived Fungus

被引：28

作者：

Chokpaiboon, Supichar ^{[2
]}

Sommit, Damrong ^{[3
]}

Bunyapaiboonsri, Taridaporn ^{[4
]}

Matsubara, Kiminori ^{[1
]}

Pudhom, Khanitha ^{[5
,6
]}

机构：

[1] Hiroshima Univ, Grad Sch Educ, Dept Human Life Sci Educ, Hiroshima 7398524, Japan

[2] Chulalongkorn Univ, Program Biotechnol, Fac Sci, Bangkok 10330, Thailand

[3] Mahanakorn Univ Technol, Dept Chem, Fac Sci, Bangkok 10530, Thailand

[4] Natl Ctr Genet Engn & Biotechnol BIOTEC, Pathum Thani 12120, Thailand

[5] Chulalongkorn Univ, Fac Sci, Dept Chem, Res Ctr Bioorgan Chem, Bangkok 10330, Thailand

[6] Chulalongkorn Univ, Ctr Petr Petrochem & Adv Mat, Bangkok 10330, Thailand

来源：

JOURNAL OF NATURAL PRODUCTS | 2011年 / 74卷 / 10期

关键词：

ENDOTHELIAL GROWTH-FACTOR; ENDOPHYTIC FUNGUS; ANGIOGENESIS; CANCER;

D O I：

10.1021/np200491g

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

As part of our ongoing efforts to investigate natural products with potential for use as cancer treatments, we have recently disclosed the cytotoxicity of unique norchamigrane (1) and chamigrane (2, 3) endoperoxides from a Thai mangrove-derived fungus. Reinvestigation of this fungus in a large-scale fermentation led to the isolation of an additional new chamigrane endoperoxide (4) and one known analogue (5). Among these isolated metabolites, compound 3 (merulin C) exhibited potent antiangiogenic activity mainly by suppression of endothelial cell proliferation and migration in a dose-dependent manner, and its effect is mediated by reduction in the phosphorylation of Erk1/2. Merulin C also displayed promising activity in a rat aortic ring sprouting (ex vivo) and a mouse Matrigel (in vivo) assay.

引用

页码：2290 / 2294

页数：5

共 19 条

[1] Diversity of endophytic fungi in the roots of mangrove species on the west coast of India [J].

Ananda, K ;

Sridhar, KR .

CANADIAN JOURNAL OF MICROBIOLOGY, 2002, 48 (10) :871-878

[2] Antiangiogenic cancer therapy [J].

Cao, YH .

SEMINARS IN CANCER BIOLOGY, 2004, 14 (02) :139-145

[3] Cytotoxic Nor-chamigrane and Chamigrane Endoperoxides from a Basidiomycetous Fungus [J].

Chokpaiboon, Supichar ;

Sommit, Damrong ;

Teerawatananond, Thapong ;

Muangsin, Nongnuj ;

Bunyapaiboonsri, Taridaporn ;

Pudhom, Khanitha .

JOURNAL OF NATURAL PRODUCTS, 2010, 73 (05) :1005-1007

[4]

Ferrara N, 1999, CURR TOP MICROBIOL, V237, P1

[5] ANGIOGENESIS IN CANCER, VASCULAR, RHEUMATOID AND OTHER DISEASE [J].

FOLKMAN, J .

NATURE MEDICINE, 1995, 1 (01) :27-31

[6] PPAR activators inhibit endothelial cell migration by targeting Akt [J].

Goetze, S ;

Eilers, F ;

Bungenstock, A ;

Kintscher, U ;

Stawowy, P ;

Blaschke, F ;

Graf, K ;

Law, RE ;

Fleck, E ;

Gräfe, M .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2002, 293 (05) :1431-1437

[7] p-aminoacetophenonic acids produced by a mangrove endophyte:: Streptomyces griseus subsp. [J].

Guan, SH ;

Sattler, I ;

Lin, WH ;

Guo, DA ;

Grabley, S .

JOURNAL OF NATURAL PRODUCTS, 2005, 68 (08) :1198-1200

[8] Marine endophyte sources of new chemical natural products: a review [J].

Jones, E. B. Gareth ;

Stanley, Susan J. ;

Pinruan, Umpava .

BOTANICA MARINA, 2008, 51 (03) :163-170

[9] Anti-angiogenic activity of the recombinant kringle domain of urokinase and its specific entry into endothelial cells [J].

Kim, KS ;

Hong, YK ;

Joe, YA ;

Lee, Y ;

Shin, JY ;

Park, HE ;

Lee, IH ;

Lee, SY ;

Kang, DK ;

Chang, SI ;

Chung, SI .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (13) :11449-11456

[10] Xanalteric Acids I and II and Related Phenolic Compounds from an Endophytic Alternaria sp Isolated from the Mangrove Plant Sonneratia alba [J].

Kjer, Julia ;

Wray, Victor ;

Edrada-Ebel, RuAngelie ;

Ebel, Rainer ;

Pretsch, Alexander ;

Lin, Wenhan ;

Proksch, Peter .

JOURNAL OF NATURAL PRODUCTS, 2009, 72 (11) :2053-2057

← 1 2 →