Human Pulmonary 3D Models For Translational Research

被引：61

作者：

Zscheppang, Katja ^{[1
]}

Berg, Johanna ^{[2
]}

Hedtrich, Sarah ^{[3
]}

Verheyen, Leonie ^{[3
]}

Wagner, Darcy E. ^{[4
]}

Suttorp, Norbert ^{[1
]}

Hippenstiel, Stefan ^{[1
]}

Hocke, Andreas C. ^{[1
]}

机构：

[1] Charite Univ Med Berlin, Dept Internal Med Infect & Resp Dis, Charitepl 1, D-10117 Berlin, Germany

[2] Tech Univ Berlin, Dept Biotechnol, Gustav Meyer Allee 25, D-13335 Berlin, Germany

[3] Free Univ Berlin, Inst Pharm Pharmacol & Toxicol, Berlin, Germany

[4] Helmholtz Zentrum Munich, Lung Repair & Regenerat Unit, Comprehens Pneumol Ctr, German Ctr Lung Res, Munich, Germany

来源：

BIOTECHNOLOGY JOURNAL | 2018年 / 13卷 / 01期

关键词：

3D models; alveolar; bronchial; human lung tissue; infections; SLOW-REACTING SUBSTANCE; HUMAN LUNG-TISSUE; BRONCHIAL EPITHELIAL-CELLS; MESENCHYMAL STEM-CELLS; IN-VITRO MODELS; CIGARETTE-SMOKE; ANIMAL-MODELS; STREPTOCOCCUS-PNEUMONIAE; GLOBAL BURDEN; PHARMACOLOGICAL CHARACTERIZATION;

D O I：

10.1002/biot.201700341

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Lung diseases belong to the major causes of death worldwide. Recent innovative methodological developments now allow more and more for the use of primary human tissue and cells to model such diseases. In this regard, the review covers bronchial air-liquid interface cultures, precision cut lung slices as well as ex vivo cultures of explanted peripheral lung tissue and de-/re-cellularization models. Diseases such as asthma or infections are discussed and an outlook on further areas for development is given. Overall, the progress in ex vivo modeling by using primary human material could make translational research activities more efficient by simultaneously fostering the mechanistic understanding of human lung diseases while reducing animal usage in biomedical research.

引用

页数：12

共 155 条

[1] Global and regional estimates of COPD prevalence: Systematic review and meta-analysis [J].

Adeloye, Davies ;

Chua, Stephen ;

Lee, Chinwei ;

Basquill, Catriona ;

Papana, Angeliki ;

Theodoratou, Evropi ;

Nair, Harish ;

Gasevic, Danijela ;

Sridhar, Devi ;

Campbell, Harry ;

Chan, Kit Yee ;

Sheikh, Aziz ;

Rudan, Igor .

JOURNAL OF GLOBAL HEALTH, 2015, 5 (02) :186-202

[2] OXYGEN METABOLITES STIMULATE RELEASE OF HIGH-MOLECULAR-WEIGHT GLYCOCONJUGATES BY CELL AND ORGAN-CULTURES OF RODENT RESPIRATORY EPITHELIUM VIA AN ARACHIDONIC ACID-DEPENDENT MECHANISM [J].

ADLER, KB ;

HOLDENSTAUFFER, WJ ;

REPINE, JE .

JOURNAL OF CLINICAL INVESTIGATION, 1990, 85 (01) :75-85

[3] An ex vivo model to induce early fibrosis-like changes in human precision-cut lung slices [J].

Alsafadi, Hani N. ;

Staab-Weijnitz, Claudia A. ;

Lehmann, Mareike ;

Lindner, Michael ;

Peschel, Britta ;

Koenigshoff, Melanie ;

Wagner, Darcy E. .

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2017, 312 (06) :L896-L902

[4] Development of an Innovative 3D Cell Culture System to Study Tumour - Stroma Interactions in Non-Small Cell Lung Cancer Cells [J].

Amann, Arno ;

Zwierzina, Marit ;

Gamerith, Gabriele ;

Bitsche, Mario ;

Huber, Julia M. ;

Vogel, Georg F. ;

Blumer, Michael ;

Koeck, Stefan ;

Pechriggl, Elisabeth J. ;

Kelm, Jens M. ;

Hilbe, Wolfgang ;

Zwierzina, Heinz .

PLOS ONE, 2014, 9 (03)

[5] Antibacterial Defense of Human Airway Epithelial Cells from Chronic Obstructive Pulmonary Disease Patients Induced by Acute Exposure to Nontypeable Haemophilus influenzae: Modulation by Cigarette Smoke [J].

Amatngalim, Gimano D. ;

Schrumpf, Jasmijn A. ;

Henic, Almira ;

Dronkers, Esther ;

Verhoosel, Renate M. ;

Ordonez, Soledad R. ;

Haagsman, Henk P. ;

Fuentes, Maria E. ;

Sridhar, Sriram ;

Aarbiou, Jamil ;

Janssen, Richard A. J. ;

Lekkerkerker, Annemarie N. ;

Hiemstra, Pieter S. .

JOURNAL OF INNATE IMMUNITY, 2017, 9 (04) :359-374

[6]

Baatz JE, 2014, IN VIVO, V28, P411

[7] Cryopreserved Human Precision-Cut Lung Slices as a Bioassay for Live Tissue Banking A Viability Study of Bronchodilation with Bitter-Taste Receptor Agonists [J].

Bai, Yan ;

Krishnamoorthy, Nandini ;

Patel, Kruti R. ;

Rosas, Ivan ;

Sanderson, Michael J. ;

Ai, Xingbin .

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2016, 54 (05) :656-663

[8]

Banerjee Audreesh, 2012, Am J Respir Cell Mol Biol, V46, P132, DOI 10.1165/rcmb.2010-0276OC

[9] Studying immunity to zoonotic diseases in the natural host - keeping it real [J].

Bean, Andrew G. D. ;

Baker, Michelle L. ;

Stewart, Cameron R. ;

Cowled, Christopher ;

Deffrasnes, Celine ;

Wang, Lin-Fa ;

Lowenthal, John W. .

NATURE REVIEWS IMMUNOLOGY, 2013, 13 (12) :851-861

[10] Risk factors for asthma: is prevention possible? [J].

Beasley, Richard ;

Semprini, Alex ;

Mitchell, Edwin A. .

LANCET, 2015, 386 (9998) :1075-1085

← 1 2 3 4 5 6 7 8 9 10 →