Endocrine methods of ovulation induction

被引：7

作者：

Balen, A ^{[1
]}

机构：

[1] Gen Infirm, Dept Obstet & Gynaecol, Leeds LS2 9NS, W Yorkshire, England

来源：

BAILLIERES CLINICAL OBSTETRICS AND GYNAECOLOGY | 1998年 / 12卷 / 04期

关键词：

anovulation; polycystic ovary syndrome; hyperinsulinaemia; clomiphene citrate; metformin; gonadotrophin therapy; follicle-stimulating hormone;

D O I：

10.1016/S0950-3552(98)80049-7

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The rationale of ovulation induction is to achieve the development of a single follicle and ultimately a singleton healthy baby. Problems faced by women with anovulatory polycystic ovary syndrome are the sensitivity of the ovary to stimulation and health issues such as obesity. This chapter will discuss medical management including strategies to lose weight, address hyperinsulinaemia with insulin-sensitizing agents, such as metformin, and outline methods of ovulation induction from the usual first-line therapy of clomiphene citrate and the subsequent use of gonadotrophin therapy in clomiphene-resistant patients. Appropriately directed surgical ovulation induction with laparoscopic ovarian diathermy appears to be as efficacious as gonadotrophin therapy but will not be discussed in the context of this chapter.

引用

页码：521 / 539

页数：19

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