Endocrine methods of ovulation induction

被引：7
作者：
Balen, A [1 ]
机构：
[1] Gen Infirm, Dept Obstet & Gynaecol, Leeds LS2 9NS, W Yorkshire, England
来源：
BAILLIERES CLINICAL OBSTETRICS AND GYNAECOLOGY | 1998年 / 12卷 / 04期
关键词：
anovulation; polycystic ovary syndrome; hyperinsulinaemia; clomiphene citrate; metformin; gonadotrophin therapy; follicle-stimulating hormone;
D O I：
10.1016/S0950-3552(98)80049-7
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
The rationale of ovulation induction is to achieve the development of a single follicle and ultimately a singleton healthy baby. Problems faced by women with anovulatory polycystic ovary syndrome are the sensitivity of the ovary to stimulation and health issues such as obesity. This chapter will discuss medical management including strategies to lose weight, address hyperinsulinaemia with insulin-sensitizing agents, such as metformin, and outline methods of ovulation induction from the usual first-line therapy of clomiphene citrate and the subsequent use of gonadotrophin therapy in clomiphene-resistant patients. Appropriately directed surgical ovulation induction with laparoscopic ovarian diathermy appears to be as efficacious as gonadotrophin therapy but will not be discussed in the context of this chapter.
引用
收藏
页码：521 / 539
页数：19
相关论文
共 123 条
[1]   Can metformin reduce insulin resistance in polycystic ovary syndrome? [J].
Acbay, O ;
Gundogdu, S .
FERTILITY AND STERILITY, 1996, 65 (05) :946-949
[2]  
ADAMS J, 1985, LANCET, V2, P1375
[3]  
[Anonymous], LHRH ITS ANALOGUES 2
[4]  
BALEN A, 1995, HUM REPROD, V10, P2233
[5]   MISCARRIAGE RATES FOLLOWING INVITRO FERTILIZATION ARE INCREASED IN WOMEN WITH POLYCYSTIC OVARIES AND REDUCED BY PITUITARY DESENSITIZATION WITH BUSERELIN [J].
BALEN, AH ;
TAN, SL ;
MACDOUGALL, J ;
JACOBS, HS .
HUMAN REPRODUCTION, 1993, 8 (06) :959-964
[6]   HYPERSECRETION OF LUTEINIZING-HORMONE - A SIGNIFICANT CAUSE OF INFERTILITY AND MISCARRIAGE [J].
BALEN, AH ;
TAN, SL ;
JACOBS, HS .
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 1993, 100 (12) :1082-1089
[7]   POLYCYSTIC-OVARY-SYNDROME - THE SPECTRUM OF THE DISORDER IN 1741 PATIENTS [J].
BALEN, AH ;
CONWAY, GS ;
KALTSAS, G ;
TECHATRAISAK, K ;
MANNING, PJ ;
WEST, C ;
JACOBS, HS .
HUMAN REPRODUCTION, 1995, 10 (08) :2107-2111
[8]   CUMULATIVE CONCEPTION AND LIVE BIRTH-RATES AFTER THE TREATMENT OF ANOVULATORY INFERTILITY - SAFETY AND EFFICACY OF OVULATION INDUCTION IN 200 PATIENTS [J].
BALEN, AH ;
BRAAT, DDM ;
WEST, C ;
PATEL, A ;
JACOBS, HS .
HUMAN REPRODUCTION, 1994, 9 (08) :1563-1570
[9]  
BALEN AH, 1997, INFERTILITY PRACTICE, P131
[10]  
Balen AH, 1994, CONT REV OBSTET GYNA, V6, P201
12345678910