Carmustine-impregnated wafers and their impact in the management of high-grade glioma

被引:3
作者
La Rocca, Renato V. [1 ]
Rezazadeh, Arash [1 ]
机构
[1] Kentuckiana Canc Inst, PLLC, Louisville, KY 40202 USA
关键词
BCNU; carmustine-impregnated wafers; glioblastoma; locoregional treatment; MALIGNANT GLIOMA; INTERSTITIAL DELIVERY; BIODEGRADABLE POLYMERS; ADJUVANT TEMOZOLOMIDE; BCNU WAFERS; GLIOBLASTOMA; CHEMOTHERAPY; SURVIVAL; TRIAL; RADIOTHERAPY;
D O I
10.1517/14656566.2011.580737
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Introduction: Carmustine-impregnated biodegradable wafers provide a locoregional adjunct to the treatment of patients with high-grade glial neoplasms. Their impact is that of delivering a chemotherapeutic agent directly to the tumor site at the time of neurosurgical intervention with a resulting increased local drug concentration and an ongoing therapeutic effect lasting several days to weeks. Areas covered: This manuscript reviews the preclinical and clinical studies that established carmustine-impregnated wafers as a locoregional therapy in the treatment of de novo as well as recurrent high-grade gliomas and compares it with other locoregional modalities currently under development. A pertinent English language literature search dating back to 1990 was undertaken. Expert opinion: Carmustine-impregnated wafers represent but one component of a multimodality armamentarium for the treatment of high-grade gliomas. The development of biodegradable compounds capable of incorporating additional therapeutic agents beyond carmustine is a subject of ongoing research. Integration of diverse treatment modalities into the management of complex high-grade cancers, taking advantage of predictive markers of efficacy, be they molecular or otherwise, will remain a major focus of clinical research in the second decade of this century.
引用
收藏
页码:1325 / 1332
页数:8
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