A proposal on porcine circovirus type 2 (PCV2) genotype definition and their relation with postweaning multisystemic wasting syndrome (PMWS) occurrence

被引：150

作者：

Grau-Roma, L. ^{[1
,2
]}

Crisci, E. ^{[1
]}

Sibila, M. ^{[1
]}

Lopez-Soria, S. ^{[1
]}

Nofrarias, M. ^{[1
]}

Cortey, M.

Fraile, L. ^{[1
]}

Olvera, A. ^{[1
]}

Segales, J. ^{[1
,2
]}

机构：

[1] Univ Autonoma Barcelona, Fac Vet, Dept Sanit & Anat Anim, Bellaterra 08193, Spain

[2] Esfera Univ Autonoma Barcelona, CReSA, Bellaterra 08193, Spain

来源：

VETERINARY MICROBIOLOGY | 2008年 / 128卷 / 1-2期

关键词：

porcine circovirus type 2 (PCV2); postweaning multisystemic wasting syndrome (PMWS); genotype; phylogeny; epidemiology; pathogenicity;

D O I：

10.1016/j.vetmic.2007.09.007

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Porcine circovirus type 2 (PCV2) is the essential infectious agent of postweaning multisystemic wasting syndrome (PMWS). Despite first sequencing studies did not find any association between PCV2 sequences and PMWS occurrence, recent works have suggested the opposite. In the present study, 87 open reading frame 2 (ORF2) sequences obtained from pigs with different clinical conditions and coming from farms with different PMWS status were analyzed. Results further confirmed the existence of two genogroups and the definition of two PCV2 genotypes (1 and 2) is proposed. All sequences included in genotype I came from pigs from PMWS affected farms, while all sequences obtained from non-PMWS affected farms corresponded to genotype 2. Moreover, infection of single pigs from PMWS affected farms harbouring both genotypes is described. Present results suggest that PCV2 genotype I may potentially be more pathogenic than PCV2 genotype 2. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：23 / 35

页数：13

共 53 条

[1] An experimental model for post-weaning multisystemic wasting syndrome (PMWS) in growing piglets [J].

Albina, E ;

Truong, C ;

Hutet, E ;

Blanchard, P ;

Cariolet, R ;

L'Hospitalier, R ;

Mahé, D ;

Allée, C ;

Morvan, H ;

Amenna, N ;

Le Dimna, M ;

Madec, F ;

Jestin, A .

JOURNAL OF COMPARATIVE PATHOLOGY, 2001, 125 (04) :292-303

[2] Reproduction of postweaning multisystemic wasting syndrome in pigs experimentally inoculated with a Swedish porcine circovirus 2 isolate [J].

Allan, G ;

McNeilly, F ;

Meehan, B ;

McNair, I ;

Ellis, J ;

Krakowka, S ;

Fossum, C ;

Wattrang, E ;

Wallgren, P ;

Adair, B .

JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION, 2003, 15 (06) :553-560

[3] Experimental reproduction of severe wasting disease by co-infection of pigs with porcine circovirus and porcine parvovirus [J].

Allan, GM ;

Kennedy, S ;

McNeilly, F ;

Foster, JC ;

Ellis, JA ;

Krakowka, SJ ;

Meehan, BM ;

Adair, BM .

JOURNAL OF COMPARATIVE PATHOLOGY, 1999, 121 (01) :1-11

[4] Determination and phylogenetic analysis of partial sequences from TT virus isolates [J].

Biagini, P ;

Gallian, P ;

Attoui, H ;

Cantaloube, JF ;

de Micco, P ;

de Lamballerie, X .

JOURNAL OF GENERAL VIROLOGY, 1999, 80 :419-424

[5]

Carman S, 2006, CAN VET J, V47, P761

[6] Detection of two porcine circovirus type 2 genotypic groups in United States swine herds [J].

Cheung, A. K. ;

Lager, K. M. ;

Kohutyuk, O. I. ;

Vincent, A. L. ;

Henry, S. C. ;

Baker, R. B. ;

Rowland, R. R. ;

Dunham, A. G. .

ARCHIVES OF VIROLOGY, 2007, 152 (05) :1035-1044

[7]

Cheung A.K., 2007, P 5 INT S EM REEM PI, P273

[8] Molecular characterization of Porcine circovirus type 2 isolates from post-weaning multisystemic wasting syndrome-affected and non-affected pigs [J].

de Boisséson, C ;

Beven, V ;

Bigarré, L ;

Thiéry, R ;

Rose, N ;

Eveno, E ;

Madec, F ;

Jestin, A .

JOURNAL OF GENERAL VIROLOGY, 2004, 85 :293-304

[9]

EXCOFFIER L, 1992, GENETICS, V131, P479

[10] Revising the way we conceive and name viruses below the species level: A review of geminivirus taxonomy calls for new standardized isolate descriptors [J].

Fauquet, CM ;

Stanley, J .

ARCHIVES OF VIROLOGY, 2005, 150 (10) :2151-2179

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