Self-assembly, photoresponsive behavior and transport potential of azobenzene grafted dendronized polymeric amphiphiles

被引：27

作者：

Kumari, Meena ^{[1
]}

Billamboz, Muriel ^{[2
]}

Leonard, Estelle ^{[2
]}

Len, Christophe ^{[2
,3
]}

Boettcher, Christoph ^{[5
]}

Prasad, Ashok K. ^{[1
]}

Haag, Rainer ^{[4
]}

Sharma, Sunil K. ^{[1
]}

机构：

[1] Univ Delhi, Dept Chem, Delhi 110007, India

[2] Univ Technol Compiegne, Univ Paris 04, Ctr Rech Royallieu, Ecole Super Chim Organ & Minerale, F-60203 Compiegne, France

[3] Univ Hull, Dept Chem, Kingston Upon Hull HU6 7RX, N Humberside, England

[4] Free Univ Berlin, Inst Chem & Biochem, D-14195 Berlin, Germany

[5] Free Univ Berlin, Inst Chem & Biochem, Forschungszentrum Elektronenmikroskopie, D-14195 Berlin, Germany

来源：

RSC ADVANCES | 2015年 / 5卷 / 60期

关键词：

CLICK CHEMISTRY; BIOMEDICAL APPLICATIONS; ALIPHATIC POLYESTERS; BLOCK-COPOLYMERS; CURCUMIN; NANOCARRIERS; FLUORESCENCE; SURFACTANT; SYSTEMS; RELEASE;

D O I：

10.1039/c5ra08047a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Photoresponsive polymeric amphiphiles were developed by first synthesizing the polyester chain via Novozym 435 catalyzed step growth, condensation polymerization of poly[ethylene glycol bis(carboxymethyl) ether]diethylester and 2-azidopropan-1,3-diol followed by grafting with 4'-butyl-4-propargyloxy(azobenzene) and [G2.0] polyglycerol dendron by using a 'Click chemistry' approach. The resulting polymers were observed to form supramolecular micellar aggregates in aqueous solution. The critical aggregation concentration (CAC) was determined via fluorescence measurements and using 'Nile red' as a probe. The nano-structures formed in the aqueous solution were characterized by dynamic light scattering (DLS) and cryo-TEM measurements. The encapsulation potential of polymeric amphiphiles for Nile red and curcumin as well as their release via trans-cis photoisomerization of the embedded azobenzene moiety was studied, by absorbance and fluorescence spectroscopy techniques. The developed polymeric micellar systems behave as efficient photoresponsive smart nanocarriers.

引用

页码：48301 / 48310

页数：10

共 59 条

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