Clinical features and microbiological characteristics of hospital- and community-onset Escherichia coli bloodstream infection

被引:9
作者
Chen, Xiao [1 ,2 ]
Zou, Qianda [1 ]
Zhang, Weili [1 ,2 ]
Wang, Ruonan [1 ]
Yu, Fei [1 ]
Chen, Yu [1 ,2 ]
机构
[1] Zhejiang Univ, Dept Clin Lab, Affiliated Hosp 1, Sch Med,Key Lab Clin Vitro Diagnost Tech Zhejiang, Hangzhou, Zhejiang, Peoples R China
[2] Zhejiang Univ, Collaborat Innovat Ctr Diag & Treatment Infect Di, Affiliated Hosp 1, State Key Lab Diag & Treatment Infect Dis,Sch Med, Hangzhou, Zhejiang, Peoples R China
关键词
Escherichia coli; bloodstream infection; ST; 131; serotype; virulence factor genes; VIRULENCE FACTORS; TRACT-INFECTIONS; HIGH PREVALENCE; RISK-FACTORS; CTX-M; BACTEREMIA; SPECTRUM; RESISTANCE; EPIDEMIOLOGY; MORTALITY;
D O I
10.1099/jmm.0.000904
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Purpose. Escherichia coli is a leading cause of bloodstream infection (BSI) in hospitals and communities. Methodology. We conducted a retrospective study in 2015 to evaluate the clinical features and microbiological characteristics of E. coli BSI acquired in the hospital and community. Results. A total of 100 patients with E. coli BSI were enrolled, among whom 60% had hospital-onset (HO) BSI while 40% had community-onset (CO) BSI. Patients with HO BSI had higher percentages of haematological disorders, immunosuppression conditions, underwent surgery within 2weeks and had a higher 30-day mortality. The prevalences of multidrug-resistant and extended-spectrum beta-lactamase-producing strains were 81 and 60%, respectively. Resistance percentages to ampicillin, ampicillin-sulbactam, cefazolin, ceftriaxone, ciprofloxacin and levofloxacin were greater than 50%. Of the 43 different sequence types (STs) identified, ST131 (15.3%) was the most common. The serum agglutination rate was 52% in which 13 O and 11 H serogroups were observed. Among the 36 detected virulence factor (VF) genes, IutA (66%) and traT (61%) were the most predominant. papA, papC and papEF were different between the CO and HO BSI groups. VF scores were high (mean >7) in the frequently detected ST95, ST1193 and ST131. Conclusion. This study revealed that the clinical features of HO and CO E. coli BSI were different. STs and serotypes showed a great diversity in this region while VF genes of the isolates varied between clones.
引用
收藏
页码:178 / 187
页数:10
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