MyoD and the transcriptional control of myogenesis

被引:646
作者
Berkes, CA [1 ]
Tapscott, SJ
机构
[1] Colorado Coll, Colorado Springs, CO 80903 USA
[2] Fred Hutchinson Canc Res Ctr, Seattle, WA 98109 USA
关键词
gene expression; myogenesis; development; chromatin;
D O I
10.1016/j.semcdb.2005.07.006
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The basic helix-loop-helix myogenic regulatory factors MyoD, Myf5, myogenin and MRF4 have critical roles in skeletal muscle development. Together with the Mef2 proteins and E proteins, these transcription factors are responsible for coordinating muscle-specific gene expression in the developing embryo. This review highlights recent studies regarding the molecular mechanisms by which the muscle-specific myogenic bHLH proteins interact with other regulatory factors to coordinate gene expression in a controlled and ordered manner. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码:585 / 595
页数:11
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