Prognostic significance of baseline neutrophil-lymphocyte ratio in patients with non-small-cell lung cancer: a pooled analysis of open phase III clinical trial data

被引：9
作者：
Huang, Liling [1 ]
Jiang, Shiyu [2 ]
Shi, Yuankai [1 ]
机构：
[1] Chinese Acad Med Sci & Peking Union Med Coll, Dept Med Oncol, Beijing Key Lab Clin Study Anticanc Mol Targeted, Natl Canc Ctr,Natl Clin Res Ctr Canc,Canc Hosp, Beijing 100021, Peoples R China
[2] Fudan Univ, Fudan Univ Shanghai Canc Ctr, Shanghai Med Coll, Dept Med Oncol, Shanghai 200032, Peoples R China
来源：
FUTURE ONCOLOGY | 2022年 / 18卷 / 14期
关键词：
neutrophil-lymphocyte ratio; NLR; non-small-cell lung cancer; prognosis; survival; IMMUNE CHECKPOINT INHIBITORS; FEBRILE NEUTROPENIA; RISK MODEL; INFLAMMATION; LYMPHOPENIA; THERAPY; CHEMOTHERAPY; TRANSFUSION; REFLECTS;
D O I：
10.2217/fon-2021-1304
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Aim: This study aimed to assess survival and hematological prognostic indicators of patients with non-small-cell lung cancer (NSCLC). Material & methods: Through the Project Data Sphere portal, two phase III clinical trial datasets were downloaded to analyze survival outcomes and related risk factors. Results: The median progression-free survival and overall survival of 756 patients with stage III-IV NSCLC were 6.2 and 14.2 months, respectively. In multivariate Cox analysis, high baseline neutrophil-lymphocyte ratio (NLR; >= 3.8) was associated with worse progression-free survival (hazard ratio: 1.37; p = 0.0004) and overall survival (hazard ratio: 1.65; p < 0.0001). In addition, it exerted an unfavorable impact on survival across multiple subgroups. Conclusions: NLR, a powerful inflammatory and immunologic indicator, is an independent prognostic indicator in patients with advanced NSCLC.
引用
收藏
页码：1679 / 1689
页数：11
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