Antitumor activity of curcumin is mediated through the induction of apoptosis in AK-5 tumor cells

被引：168

作者：

Khar, A ^{[1
]}

Ali, AM ^{[1
]}

Pardhasaradhi, BVV ^{[1
]}

Begum, Z ^{[1
]}

Anjum, R ^{[1
]}

机构：

[1] Ctr Cellular & Mol Biol, Hyderabad 500007, Andhra Pradesh, India

来源：

FEBS LETTERS | 1999年 / 445卷 / 01期

关键词：

AK-5; apoptosis; curcumin; tumor growth; caspase-3;

D O I：

10.1016/S0014-5793(99)00114-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Curcumin, the yellow pigment of turmeric (Curcuma longa), used commonly as a spice, has been shown to possess anticarcinogenic activity. Curcumin inhibited AK-5 tumor growth and induced apoptosis in AK-5 cells. Curcumin induced apoptosis is mediated through the activation of caspase-3, which is specifically inhibited by the tetrapeptide Ac-DEVD-CHO, In addition, curcumin induced tumor cell death is caused through the generation of reactive oxygen intermediates which is inhibited by N-acetyl-L-cysteine. Our studies suggest that the apoptotic process induced by curcumin is the mechanism mediating AK-5 tumor cell death. (C) 1999 Federation of European Biochemical Societies.

引用

页码：165 / 168

页数：4

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