TGF-β regulates Sca-1 expression and plasticity of pre-neoplastic mammary epithelial stem cells

被引：5
|
作者：
Remsik, Jan [1 ,2 ,3 ,5 ]
Pickova, Marketa [1 ,2 ,3 ]
Vacek, Ondrej [1 ,2 ,3 ]
Fedr, Radek [1 ,2 ]
Bino, Lucia [1 ,2 ]
Hampl, Ales [2 ,4 ]
Soucek, Karel [1 ,2 ,3 ]
机构：
[1] Czech Acad Sci, Inst Biophys, Kralovopolska 135, Brno 61265, Czech Republic
[2] St Annes Univ Hosp Brno, Ctr Biomol & Cellular Engn, Int Clin Res Ctr, Pekarska 53, Brno 65691, Czech Republic
[3] Masaryk Univ, Fac Sci, Dept Expt Biol, Kamenice 5, Brno 62500, Czech Republic
[4] Masaryk Univ, Fac Med, Dept Histol & Embryol, Kamenice 5, Brno 62500, Czech Republic
[5] Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Progra, New York, NY 10065 USA
来源：
SCIENTIFIC REPORTS | 2020年 / 10卷 / 01期
关键词：
DIFFERENTIATION; IDENTIFICATION; PROMOTES; STATE;
D O I：
10.1038/s41598-020-67827-4
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The epithelial-mesenchymal plasticity, in tight association with stemness, contributes to the mammary gland homeostasis, evolution of early neoplastic lesions and cancer dissemination. Focused on cell surfaceome, we used mouse models of pre-neoplastic mammary epithelial and cancer stem cells to reveal the connection between cell surface markers and distinct cell phenotypes. We mechanistically dissected the TGF-beta family-driven regulation of Sca-1, one of the most commonly used adult stem cell markers. We further provided evidence that TGF-beta disrupts the lineage commitment and promotes the accumulation of tumor-initiating cells in pre-neoplastic cells.
引用
收藏
页数：12
相关论文
共 33 条
  • [31] miR-181b-5p mediates TGF-β1-induced epithelial-to-mesenchymal transition in non-small cell lung cancer stem-like cells derived from lung adenocarcinoma A549 cells
    Li, Xuetao
    Han, Jing
    Zhu, Haizhen
    Peng, Lina
    Chen, Zhengtang
    INTERNATIONAL JOURNAL OF ONCOLOGY, 2017, 51 (01) : 158 - 168
  • [32] Active STAT5 Regulates T-bet and Eomesodermin Expression in CD8 T Cells and Imprints a T-bet-Dependent Tc1 Program with Repressed IL-6/TGF-β1 Signaling
    Grange, Magali
    Verdeil, Gregory
    Arnoux, Fanny
    Griffon, Aurelien
    Spicuglia, Salvatore
    Maurizio, Julien
    Buferne, Michel
    Schmitt-Verhulst, Anne-Marie
    Auphan-Anezin, Nathalie
    JOURNAL OF IMMUNOLOGY, 2013, 191 (07) : 3712 - 3724
  • [33] Adipose derived stem cells (ASCs) isolated from breast cancer tissue express IL-4, IL-10 and TGF-β1 and upregulate expression of regulatory molecules on T cells: Do they protect breast cancer cells from the immune response?
    Razmkhah, Mahboobeh
    Jaberipour, Mansooreh
    Erfani, Nasrollah
    Habibagahi, Mojtaba
    Talei, Abdol-rasoul
    Ghaderi, Abbas
    CELLULAR IMMUNOLOGY, 2011, 266 (02) : 116 - 122
1234