TGF-β regulates Sca-1 expression and plasticity of pre-neoplastic mammary epithelial stem cells

被引：5
|
作者：
Remsik, Jan [1 ,2 ,3 ,5 ]
Pickova, Marketa [1 ,2 ,3 ]
Vacek, Ondrej [1 ,2 ,3 ]
Fedr, Radek [1 ,2 ]
Bino, Lucia [1 ,2 ]
Hampl, Ales [2 ,4 ]
Soucek, Karel [1 ,2 ,3 ]
机构：
[1] Czech Acad Sci, Inst Biophys, Kralovopolska 135, Brno 61265, Czech Republic
[2] St Annes Univ Hosp Brno, Ctr Biomol & Cellular Engn, Int Clin Res Ctr, Pekarska 53, Brno 65691, Czech Republic
[3] Masaryk Univ, Fac Sci, Dept Expt Biol, Kamenice 5, Brno 62500, Czech Republic
[4] Masaryk Univ, Fac Med, Dept Histol & Embryol, Kamenice 5, Brno 62500, Czech Republic
[5] Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Progra, New York, NY 10065 USA
来源：
SCIENTIFIC REPORTS | 2020年 / 10卷 / 01期
关键词：
DIFFERENTIATION; IDENTIFICATION; PROMOTES; STATE;
D O I：
10.1038/s41598-020-67827-4
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The epithelial-mesenchymal plasticity, in tight association with stemness, contributes to the mammary gland homeostasis, evolution of early neoplastic lesions and cancer dissemination. Focused on cell surfaceome, we used mouse models of pre-neoplastic mammary epithelial and cancer stem cells to reveal the connection between cell surface markers and distinct cell phenotypes. We mechanistically dissected the TGF-beta family-driven regulation of Sca-1, one of the most commonly used adult stem cell markers. We further provided evidence that TGF-beta disrupts the lineage commitment and promotes the accumulation of tumor-initiating cells in pre-neoplastic cells.
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收藏
页数：12
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