Macrophage migration inhibitory factor reduces apoptosis in cerebral arteriovenous malformations

被引：16

作者：

Chen, Guangzhong ^{[1
,2
]}

Zheng, Meng ^{[1
,2
]}

Shu, Hang ^{[1
,2
]}

Zhan, Shengquan ^{[1
,2
]}

Wang, Hongqin ^{[1
,2
]}

Zhou, Dong ^{[1
,2
]}

Zeng, Shaojian ^{[1
,2
]}

Tang, Kai ^{[1
,2
]}

Feng, Lei ^{[3
]}

机构：

[1] Guangdong Gen Hosp, Dept Neurosurg, Guangzhou 510080, Guangdong, Peoples R China

[2] Guangdong Acad Med Sci, Inst Neurosci, Guangzhou 510080, Guangdong, Peoples R China

[3] Univ Calif Los Angeles, David Geffen Sch Med, Div Intervent Neuroradiol, Los Angeles, CA 90095 USA

来源：

NEUROSCIENCE LETTERS | 2012年 / 508卷 / 02期

关键词：

Cerebral arteriovenous malformation; Macrophage migration inhibitory factor; Caspase-3; Apoptosis; ENDOTHELIAL-CELLS; UP-REGULATION; EXPRESSION; ATHEROSCLEROSIS; ANGIOGENESIS; BRAIN; PATHWAY; DISEASE; TARGET; GENE;

D O I：

10.1016/j.neulet.2011.12.024

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Purpose: To investigate the expression of macrophage migration inhibitory factor (MIF) in human brain arteriovenous malformations (AVM). Materials and methods: Twelve AVM specimens were obtained from patients who did not received preoperative embolization. MIF levels were measured by Western blot and matrix metalloproteinase 9 (MMP9) levels were measured by reverse transcription PCR The expression of MIF in brain AVMs was also evaluated by immunohistochemistry and was correlated with apoptosis and the expression of cleaved caspase-3 and MMP9. Results: The expression of MIF. MMP9, and cleaved caspase-3 was elevated in brain AVM vessels. High levels of MIF were primarily found in the endothelium and adventitia, whereas apoptotic cells were concentrated in the smooth muscle layer. Conclusions: Abnormal apoptosis may be involved in the pathogenesis of brain AVM. In addition, increased MIF expression could play an important role regulating the homeostasis of AVM vessels. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

引用

页码：84 / 88

页数：5

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