The use of a test battery assessing affective behavior in rats: Order effects

被引：59

作者：

Blokland, Arjan ^{[1
]}

ten Oever, Sanne ^{[1
]}

van Gorp, Dennis ^{[1
]}

van Draanen, Michael ^{[1
]}

Schmidt, Theodor ^{[1
]}

Nguyen, Emily ^{[1
]}

Krugliak, Alexandra ^{[1
]}

Napoletano, Anthony ^{[1
]}

Keuter, Sarah ^{[1
]}

Klinkenberg, Inge ^{[1
]}

机构：

[1] Maastricht Univ, Fac Psychol & Neurosci, Dept Neuropsychol & Psychopharmacol, NL-6200 MD Maastricht, Netherlands

来源：

BEHAVIOURAL BRAIN RESEARCH | 2012年 / 228卷 / 01期

关键词：

Anxiety; Depression; Animal model; Order effect; Forced Swim Test; Open Field; Zero Maze; ELEVATED PLUS-MAZE; ANIMAL-MODEL; OPEN-FIELD; CIRCADIAN PHASE; ZERO-MAZE; ANXIETY; MICE; ILLUMINATION; ENVIRONMENT; STRAINS;

D O I：

10.1016/j.bbr.2011.11.042

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Many studies have used test batteries for the evaluation of affective behavior in rodents. This has the advantage that treatment effects can be examined on different aspects of the affective domain. However, the behavior in one test may affect the behavior in following test. The present study examined possible order effects in rats that were tested in three different tests: Open Field (OF), Zero Maze (ZM) and Forced Swim Test (FST). The data of the present study indicated that the behavior in ZM was the least affected by the order of testing. In contrast, the behavior in the FST (and to a less extend the OF) was dependent on the order of the test in the test battery. Repeated testing in the same test did not change the behavior in the ZM. However, the behavior in the OF and FST changed with repeated testing. The present study indicates that the performance of rats in a test can be dependent on the order in a test battery. Consequently, these data caution the interpretation of treatment effects in studies in which test batteries are used. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：16 / 21

页数：6

共 31 条

[1] Behavioural differences between C57BL/6 and 129S6/SvEv strains are reinforced by environmental enrichment [J].