One-Step Fabrication of Supramolecular Microcapsules from Microfluidic Droplets

被引：401
作者：
Zhang, Jing
Coulston, Roger J. [1 ]
Jones, Samuel T. [1 ]
Geng, Jin [1 ]
Scherman, Oren A. [1 ]
Abell, Chris [1 ]
机构：
[1] Univ Cambridge, Dept Chem, Melville Lab Polymer Synth, Cambridge CB2 1EW, England
来源：
SCIENCE | 2012年 / 335卷 / 6069期
基金：
英国工程与自然科学研究理事会; 欧洲研究理事会;
关键词：
CONTROLLED MORPHOLOGY; POLYMER CAPSULES; ENCAPSULATION; CHEMISTRY; RELEASE; DEVICE; CARGO;
D O I：
10.1126/science.1215416
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Although many techniques exist for preparing microcapsules, it is still challenging to fabricate them in an efficient and scalable process without compromising functionality and encapsulation efficiency. We demonstrated a simple one-step approach that exploits a versatile host-guest system and uses microfluidic droplets to generate porous microcapsules with easily customizable functionality. The capsules comprise a polymer-gold nanoparticle composite held together by cucurbit[8]uril ternary complexes. The dynamic yet highly stable micrometer-sized structures can be loaded in one step during capsule formation and are amenable to on-demand encapsulant release. The internal chemical environment can be probed with surface enhanced Raman spectroscopy.
引用
收藏
页码：690 / 694
页数：5
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