Effect of breviscapine injection on clinical parameters in diabetic nephropathy: A meta-analysis of randomized controlled trials

被引:27
|
作者
Liu, Xiaodan [1 ]
Yao, Li [1 ]
Sun, Da [1 ]
Zhu, Xinwang [1 ]
Liu, Qiang [1 ]
Xu, Tianhua [1 ]
Wang, Lining [1 ]
机构
[1] China Med Univ, Affiliated Hosp 1, Dept Nephrol, 155 Nanjing North St, Shenyang 110001, Liaoning, Peoples R China
关键词
breviscapine; diabetic nephropathy; urine protein; renal function; blood fat; KIDNEY-DISEASE; DYSLIPIDEMIA; STAGE;
D O I
10.3892/etm.2016.3483
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Diabetic nephropathy (DN) is currently a major public health problem worldwide. The objective of the present study was to evaluate the clinical effect of breviscapine injections in patients with DN. A meta-analysis was performed using the following databases to obtain published reports in any language: PubMed/MEDLINE, Embase, China National Knowledge Infrastructure, Chinese Evidence-Based Medicine, Wanfang Digital Periodicals, Chinese Academic Journals Full-text Database, Chinese Biological and Medical Database, China Doctoral and Masters Dissertations Full-text Database and the Chinese Proceedings of Conference Full-text Database. Two assessors independently reviewed each trial. A total of 35 randomized controlled trials, which performed studies on a total of 2,320 patients (1,188 in treatment groups and 1,132 in control groups), were included in the present meta-analysis. Data were analyzed using Stata version 11.0 for Windows. The results from the analysis demonstrated that breviscapine injections have greater therapeutic effects in patients with DN in comparison with the control group, including renal protective effects (reducing urine protein, serum creatinine and blood urea nitrogen) and adjustment for dyslipidemia (affecting levels of cholesterol, triglycerides and high density lipoproteins). These effects indicate that breviscapine injections are beneficial to patients with DN. Further studies are required to determine the mechanisms underlying the therapeutic effects of breviscapine.
引用
收藏
页码:1383 / 1397
页数:15
相关论文
共 50 条
  • [21] Meta-Analysis of the Clinical Effect of Ligustrazine on Diabetic Nephropathy
    Wang, Bin
    Ni, Qing
    Wang, Xun
    Lin, Lan
    AMERICAN JOURNAL OF CHINESE MEDICINE, 2012, 40 (01): : 25 - 37
  • [22] Immunosuppressive treatments for immunoglobulin A nephropathy: A meta-analysis of randomized controlled trials
    Samuels, JA
    Strippoli, GFM
    Craig, JC
    Schena, FP
    Molony, DA
    NEPHROLOGY, 2004, 9 (04) : 177 - 185
  • [23] The effects of omega-3 fatty acids on diabetic nephropathy: A meta-analysis of randomized controlled trials
    Chewcharat, Api
    Chewcharat, Pol
    Rutirapong, Anawin
    Papatheodorou, Stefania
    PLOS ONE, 2020, 15 (02):
  • [24] Parenteral selenium for the clinical effect of sepsis: A meta-analysis of randomized controlled trials
    He, Shendi
    Cao, Beibei
    Yu, Hui
    Zhen, Junhai
    Wang, Fei
    PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2020, 33 (06) : 2679 - 2686
  • [25] Acetylcysteine prevents contrast nephropathy: Meta-analysis of randomized clinical trials
    Isenbarger, DW
    Kent, SM
    O'Malley, PG
    CIRCULATION, 2003, 108 (17) : 459 - 459
  • [26] Efficacy of statins in patients with diabetic nephropathy: a meta-analysis of randomised controlled trials
    Shen, X.
    Zhou, X. J.
    Zhang, Z. W.
    Zhang, X. Q.
    Zhao, J. Y.
    Xu, Q. L.
    Shang, H. X.
    Xie, T. Y.
    Dong, J. J.
    Liao, L.
    DIABETOLOGIA, 2016, 59 : S485 - S485
  • [27] Serum TGF-β1 as a Biomarker for Type 2 Diabetic Nephropathy: A Meta-Analysis of Randomized Controlled Trials
    Mou, Xin
    Zhou, Di-Yi
    Zhou, Dan-Yang
    Ma, Jing-Ru
    Liu, Ying-Hui
    Chen, Hui-Ping
    Hu, Yong-Bin
    Shou, Cheng-Min
    Chen, Jia-Wei
    Liu, Wen-Hong
    Ma, Guo-Ling
    PLOS ONE, 2016, 11 (02):
  • [28] Clinical Efficacy of Jinshuibao Capsules Combined with Angiotensin Receptor Blockers in Patients with Early Diabetic Nephropathy: A Meta-Analysis of Randomized Controlled Trials
    Lu, Qiang
    Li, Cailan
    Chen, Weiwen
    Shi, Zhongfeng
    Zhan, Ruoting
    He, Rui
    EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2018, 2018
  • [29] Effects of dietary intervention on diabetic nephropathy: an umbrella review of systematic review and meta-analysis of randomized controlled trials
    Cai, Linli
    NEPHROLOGY DIALYSIS TRANSPLANTATION, 2024, 39 : I191 - I192
  • [30] Effects of soy isoflavone supplementation on patients with diabetic nephropathy: a systematic review and meta-analysis of randomized controlled trials
    Wang, Xue
    Liang, Qing-Feng
    Zeng, Xia
    Huang, Guang-Xiao
    Xin, Gui-Zhong
    Xu, You-Hua
    Wang, Shu-Mei
    Tang, Dan
    FOOD & FUNCTION, 2021, 12 (17) : 7607 - 7618