Integrin activation by talin, kindlin and mechanical forces

被引：389

作者：

Sun, Zhiqi ^{[1
]}

Costell, Mercedes ^{[2
]}

Faessler, Reinhard ^{[1
]}

机构：

[1] Max Planck Inst Biochem, Martinsried, Germany

[2] Univ Valencia, Valencia, Spain

来源：

NATURE CELL BIOLOGY | 2019年 / 21卷 / 01期

关键词：

STRUCTURAL BASIS; NANOSCALE ARCHITECTURE; ADHESION; SHARPIN; CONFORMATION; RECOGNITION; TRANSDUCTION; INFLAMMATION; EXTENSION; MEMBRANE;

D O I：

10.1038/s41556-018-0234-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Integrins are the major family of adhesion molecules that mediate cell adhesion to the extracellular matrix. They are essential for embryonic development and influence numerous diseases, including inflammation, cancer cell invasion and metastasis. In this Perspective, we discuss the current understanding of how talin, kindlin and mechanical forces regulate integrin affinity and avidity, and how integrin inactivators function in this framework.

引用

页码：25 / 31

页数：7

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