ent-kaurane diterpenoids from Isodon japonicus

被引：33

作者：

Hong, Seong Su ^{[1
]}

Lee, Seon A. ^{[1
]}

Han, Xiang Hua ^{[1
]}

Hwang, Ji Sang ^{[1
]}

Lee, Chul ^{[1
]}

Lee, Dongho ^{[2
]}

Hong, Jin Tae ^{[1
]}

Kim, Youngsoo ^{[1
]}

Lee, Heesoon ^{[1
]}

Hwang, Bang Yeon ^{[1
]}

机构：

[1] Chungbuk Natl Univ, Coll Pharm, Cheongju 361763, South Korea

[2] Korea Univ, Coll Life Sci & Biotechnol, Seoul 136713, South Korea

来源：

JOURNAL OF NATURAL PRODUCTS | 2008年 / 71卷 / 06期

关键词：

D O I：

10.1021/np0705965

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Five ent-kaurane diterpenoids, 6 beta,7 beta, 14 beta-trihydroxy-1 alpha,19-diacetoxy-7 alpha,20-epoxy-ent-kaur-16-en-15-one (1), 1 alpha,6 beta,7 beta-trihydroxy-11 alpha,19-diacetoxy-7 alpha,20-epoxy-ent-kaur-16-en-15-one (2), 6-hydroxy-1 alpha,19-diacetoxy-6,7-seco-ent-kaur-16en-15-one-7,20-olide (3), 19-hydroxy-1 alpha,6-diacetoxy-6,7-seco-ent-kaur-16-en-15-one-7,20-olide (4), and 6-aldehyde-1 alpha,19-diacetoxy-6,7-seco-ent-kaur-16-en-15-one-7,20-olide (5), along with 10 known ent-kaurane diterpenoids, pseurata C (6), longikaurin C (7), effusanin C (8), longikaurin B (9), longikaurin D (10), effusanin D (11), excisanin B (12), lasiokaurin (13), megathyrin A (14), and loxothyrin A (15), were isolated from the aerial parts of Isodon japonicus. Their structures were determined on the basis of spectroscopic (1D-, 2D-NMR and MS) and chemical evidence. The isolates were evaluated for their inhibitory effects on LPS-induced production of nitric oxide in murine macrophage RAW264.7 cells.

引用

页码：1055 / 1058

页数：4

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