Long Non-coding RNAs: Pivotal Epigenetic Regulators in Diabetic Retinopathy

被引：3

作者：

Song, Zhaoxia ^{[1
]}

He, Chang ^{[2
]}

Wen, Jianping ^{[1
]}

Yang, Jianli ^{[1
]}

Chen, Peng ^{[1
]}

机构：

[1] Jilin Univ, Coll Basic Med Sci, Dept Genet, Room 413,126 Xinmin St, Changchun 130021, Jilin, Peoples R China

[2] Jilin Univ, Coll Basic Med Sci, Dept Mol Biol, Changchun, Peoples R China

来源：

CURRENT GENOMICS | 2022年 / 23卷 / 04期

关键词：

Diabetic retinopathy; lncRNAs; miRNAs; epigenetics; regulator; histone modification; NF-KAPPA-B; MOLECULAR-MECHANISMS; CELL-PROLIFERATION; GASTRIC-CANCER; ANRIL; MEG3; EXPRESSION; MICRORNAS; HOTAIR; METASTASIS;

D O I：

10.2174/1389202923666220531105035

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Diabetic retinopathy (DR) is a severe complication of diabetes; however, its mechanism is not fully understood. Evidence has recently revealed that long non-coding RNAs (lncRNAs) are abnormally expressed in DR, and lncRNAs may function as pivotal regulators. LncRNAs are able to modulate gene expression at the epigenetic level by acting as scaffolds of histone modification complexes and sponges of binding with microRNAs (miRNAs). LncRNAs are believed to be important epigenetic regulators, which may become beneficial in the diagnosis and therapy of DR. However, the mechanisms of lncRNAs in DR are still unclear. In this review, we summarize the possible functions and mechanisms of lncRNAs in epigenetic regulation to target genes in the progression of DR.

引用

页码：246 / 261

页数：16

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