Human brown adipose tissue: Classical brown rather than brite/beige?

被引:51
作者
Cannon, Barbara [1 ]
de Jong, Jasper M. A. [1 ,2 ]
Fischer, Alexander W. [1 ,3 ,4 ]
Nedergaard, Jan [1 ]
Petrovic, Natasa [1 ]
机构
[1] Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, SE-10691 Stockholm, Sweden
[2] Yale Sch Med, Dept Comparat Med, New Haven, CT USA
[3] Harvard Sch Publ Hlth, Dept Mol Metab, Boston, MA USA
[4] Harvard Med Sch, Dept Cell Biol, Boston, MA 02115 USA
基金
瑞典研究理事会;
关键词
beige fat; brown fat; thermoneutrality; DIET-INDUCED THERMOGENESIS; DISTINCT; ADIPOCYTES; MOUSE; MICE; UCP1; FAT; IDENTIFICATION; OBESITY; BRITE;
D O I
10.1113/EP087875
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
New Findings What is the topic of this review? It has been suggested that human brown adipose tissue (BAT) is more similar to the brite/beige adipose tissue of mice than to classical BAT of mice. The basis of this is discussed in relationship to the physiological conditions of standard experimental mice.
引用
收藏
页码:1191 / 1200
页数:10
相关论文
共 43 条
  • [1] Cidea improves the metabolic profile through expansion of adipose tissue
    Abreu-Vieira, Gustavo
    Fischer, Alexander W.
    Mattsson, Charlotte
    de Jong, Jasper M. A.
    Shabalina, Irina G.
    Ryden, Mikael
    Laurencikiene, Jurga
    Arner, Peter
    Cannon, Barbara
    Nedergaard, Jan
    Petrovic, Natasa
    [J]. NATURE COMMUNICATIONS, 2015, 6
  • [2] Gene-specific patterns of expression variation across organs and species
    Breschi, Alessandra
    Djebali, Sarah
    Gillis, Jesse
    Pervouchine, Dmitri D.
    Dobin, Alex
    Davis, Carrie A.
    Gingeras, Thomas R.
    Guigo, Roderic
    [J]. GENOME BIOLOGY, 2016, 17
  • [3] Brown adipose tissue: Function and physiological significance
    Cannon, B
    Nedergaard, J
    [J]. PHYSIOLOGICAL REVIEWS, 2004, 84 (01) : 277 - 359
  • [4] Prediction of Adipose Browning Capacity by Systematic Integration of Transcriptional Profiles
    Cheng, Yiming
    Jiang, Li
    Keipert, Susanne
    Zhang, Shuyue
    Hauser, Andreas
    Graf, Elisabeth
    Strom, Tim
    Tschoep, Matthias
    Jastroch, Martin
    Perocchi, Fabiana
    [J]. CELL REPORTS, 2018, 23 (10): : 3112 - 3125
  • [5] Reversal of hypermetabolic brown adipose tissue in F-18FDG PET imaging
    Christensen, CR
    Clark, RB
    Morton, KA
    [J]. CLINICAL NUCLEAR MEDICINE, 2006, 31 (04) : 193 - 196
  • [6] Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat
    Cypess, Aaron M.
    White, Andrew P.
    Vemochet, Cecile
    Schulz, Tim J.
    Xue, Ruidan
    Sass, Christina A.
    Huang, Tian Liang
    Roberts-Toler, Carla
    Weiner, Lauren S.
    Sze, Cathy
    Chacko, Aron T.
    Deschamps, Laura N.
    Herder, Lindsay M.
    Truchan, Nathan
    Glasgow, Allison L.
    Holman, Ashley R.
    Gavrila, Alina
    Hasselgren, Per-Olof
    Mori, Marcelo A.
    Molla, Michael
    Tseng, Yu-Hua
    [J]. NATURE MEDICINE, 2013, 19 (05) : 635 - 639
  • [7] Identification and Importance of Brown Adipose Tissue in Adult Humans.
    Cypess, Aaron M.
    Lehman, Sanaz
    Williams, Gethin
    Tal, Ilan
    Rodman, Dean
    Goldfine, Allison B.
    Kuo, Frank C.
    Palmer, Edwin L.
    Tseng, Yu-Hua
    Doria, Alessandro
    Kolodny, Gerald M.
    Kahn, C. Ronald
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2009, 360 (15) : 1509 - 1517
  • [8] Human brown adipose tissue is phenocopied by classical brown adipose tissue in physiologically humanized mice
    de Jong, Jasper M. A.
    Sun, Wenfei
    Pires, Nuno D.
    Frontini, Andrea
    Balaz, Miroslav
    Jespersen, Naja Z.
    Feizi, Amir
    Petrovic, Katarina
    Fischer, Alexander W.
    Bokhari, Muhammad Hamza
    Niemi, Tarja
    Nuutila, Pirjo
    Cinti, Saverio
    Nielsen, Soren
    Scheele, Camilla
    Virtanen, Kirsi
    Cannon, Barbara
    Nedergaard, Jan
    Wolfrum, Christian
    Petrovic, Natasa
    [J]. NATURE METABOLISM, 2019, 1 (08) : 830 - 843
  • [9] A stringent validation of mouse adipose tissue identity markers
    de Jong, Jasper M. A.
    Larsson, Ola
    Cannon, Barbara
    Nedergaard, Jan
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2015, 308 (12): : E1085 - E1105
  • [10] THE CRITICAL TEMPERATURE IN NAKED MAN
    ERIKSON, H
    KROG, J
    ANDERSEN, KL
    SCHOLANDER, PF
    [J]. ACTA PHYSIOLOGICA SCANDINAVICA, 1956, 37 (01): : 35 - 39