Potent imidazole and triazole CB1 receptor antagonists related to SR141716

被引：75

作者：

Dyck, B

Goodfellow, VS

Phillips, T

Grey, J

Haddach, M

Rowbottom, M

Naeve, GS

Brown, B

Saunders, J

机构：

[1] Neurocrine Biosci Inc, Dept Med Chem, San Diego, CA 92121 USA

[2] Neurocrine Biosci Inc, Dept Mol Biol & Pharmacol, San Diego, CA 92121 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 05期

关键词：

D O I：

10.1016/j.bmcl.2003.12.068

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Diarylimidazolecarboxamides and diaryltriazolecarboxamides related to SR141716 were synthesized and tested for binding to the human CB1 receptor. Suitably substituted imidazoles are comparably potent to the clinical candidate, whereas the analogous triazoles are less so due to the absence of an additional substituent on the azole ring. (C) 2004 Elsevier Ltd. All rights reserved.

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页码：1151 / 1154

页数：4

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