Iron-Catalysed Aerobic Oxidative C-C Bond Cleavage of Ketones for the Synthesis of Primary Amides

被引：3

作者：

Zhan, Haosheng ^{[1
]}

Hu, Zhiwei ^{[1
]}

Tao, Weihua ^{[1
]}

Ling, Min ^{[1
]}

Cao, Wei ^{[1
]}

Lin, Jing ^{[1
]}

Liu, Zhenhua ^{[2
]}

Wang, Yu ^{[1
]}

Fang, Zhongxue ^{[1
]}

机构：

[1] Yancheng Teachers Univ, Sch Chem & Environm Engn, Yancheng 224007, Peoples R China

[2] Shandong Normal Univ, Coll Chem Chem Engn & Mat Sci, Jinan 250014, Shandong, Peoples R China

来源：

SYNOPEN | 2019年 / 3卷 / 01期

基金：

中国国家自然科学基金;

关键词：

C-C bond cleavage; ketone; primary amide; amide; iron-catalysis; METHYL KETONES; ALCOHOLS; IODINE; ACIDS; TRANSFORMATION; ACTIVATION; BENZAMIDES; ALDEHYDES; HYDRATION; MILD;

D O I：

10.1055/s-0037-1611676

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An iron-catalysed aerobic oxidative C-C bond cleavage of ketones for the synthesis of primary amides has been developed using TEMPO and oxygen as an oxidant. This reaction tolerates a wide range of substrates, and primary amides are obtained in good to excellent yields. Substrates with long-chain alkyl substituents could also be selectively cleaved and converted into the corresponding amides.

引用

页码：16 / 20

页数：5

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