Potential Strategies in the Prevention of Nonsteroidal Anti-inflammatory Drugs-Associated Adverse Effects in the Lower Gastrointestinal Tract

被引：40

作者：

Guo, Chuan-Guo ^{[1
]}

Leung, Wai K. ^{[1
]}

机构：

[1] Univ Hong Kong, Li Ka Shing Fac Med, Dept Med, Hong Kong, Peoples R China

来源：

GUT AND LIVER | 2020年 / 14卷 / 02期

关键词：

Anti-inflammatory agents; non-steroidal; Lower gastrointestinal bleeding; Protective agents; LOW-DOSE ASPIRIN; SMALL-INTESTINAL INJURY; PROTON-PUMP INHIBITORS; INDOMETHACIN-INDUCED CHANGES; INFLAMMATORY-BOWEL-DISEASE; ILEAL ULCER FORMATION; NITRIC-OXIDE; DOUBLE-BLIND; GASTRIC-ULCER; HELICOBACTER-PYLORI;

D O I：

10.5009/gnl19201

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

With the increasing use of nonsteroidal anti-inflammatory drugs (NSAIDs), the incidence of lower gastrointestinal (GI) complications is expected to increase. However, unlike upper GI complications, the burden, pathogenesis, prevention and treatment of NSAID-associated lower GI complications remain unclear. To date, no cost-effective and safe protective agent has been developed that can completely prevent or treat NSAID-related lower GI injuries. Selective COX-2 inhibitors, misoprostol, intestinal microbiota modulation, and some mucoprotective agents have been reported to show protective effects on NSAID-induced lower GI injuries. This review aims to provide an overview of the current evidence on the prevention of NSAID-related lower GI injuries.

引用

页码：179 / 189

页数：11

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