Perspective: Mitochondria-ER Contacts in Metabolic Cellular Stress Assessed by Microscopy

被引：25
作者：
Stacchiotti, Alessandra [1 ,2 ,3 ]
Favero, Gaia [1 ]
Lavazza, Antonio [4 ]
Garcia-Gomez, Raquel [5 ]
Monsalve, Maria [5 ]
Rezzani, Rita [1 ,2 ]
机构：
[1] Univ Brescia, Dept Clin & Expt Sci, Anat & Physiopathol Div, Viale Europa 11, I-25123 Brescia, Italy
[2] Univ Brescia, Interdipartimental Univ Ctr Res Adaptat & Regener, I-25123 Brescia, Italy
[3] Concord Hosp, ANZAC Res Inst, Sydney, NSW 2139, Australia
[4] IZSLER, I-25124 Brescia, Italy
[5] UAM, CSIC, Inst Invest Biomed Alberto Sols, Madrid 28029, Spain
来源：
CELLS | 2019年 / 8卷 / 01期
关键词：
mitochondria; endoplasmic reticulum; MERCs; MAMs; obesity; neurodegenerative diseases; microscopy; ENDOPLASMIC-RETICULUM; CRISTAE; MAM; MEMBRANES; DYNAMICS; MECHANISMS; INTEGRITY; BIOLOGY; FORM;
D O I：
10.3390/cells8010005
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The interplay of mitochondria with the endoplasmic reticulum and their connections, called mitochondria-ER contacts (MERCs) or mitochondria-associated ER membranes (MAMs), are crucial hubs in cellular stress. These sites are essential for the passage of calcium ions, reactive oxygen species delivery, the sorting of lipids in whole-body metabolism. In this perspective article, we focus on microscopic evidences of the pivotal role of MERCs/MAMs and their changes in metabolic diseases, like obesity, diabetes, and neurodegeneration.
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页数：9
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