Repetitive transcranial magnetic stimulation: Re-wiring the alcoholic human brain

被引：8

作者：

Diana, Marco ^{[1
]}

Bolloni, Corinna ^{[1
]}

Antonelli, Mariangela ^{[2
]}

Di Giuda, Daniela ^{[3
]}

Cocciolillo, Fabrizio ^{[3
]}

Fattore, Liana ^{[4
]}

Addolorato, Giovanni ^{[2
]}

机构：

[1] Univ Sassari, Dept Chem & Pharm, Lab Cognit Neurosci G Minardi, Via Muroni 23, I-07100 Sassari, Italy

[2] Univ Cattolica Sacro Cuore, Dept Internal Med Gastroenterol & Hepatol, Alcohol Use Disorder Unit, Rome, Italy

[3] Univ Cattolica Sacro Cuore, Inst Nucl Med, Rome, Italy

[4] CNR, Inst Neurosci Cagliari, Natl Res Council, Rome, Italy

来源：

ALCOHOL | 2019年 / 74卷

关键词：

Alcohol; Transcranial magnetic stimulation; Alcohol intake; Abstinence; THETA-BURST-STIMULATION; DORSOLATERAL PREFRONTAL CORTEX; LONG-TERM DEPRESSION; DOPAMINE TRANSPORTER AVAILABILITY; POSITRON-EMISSION-TOMOGRAPHY; MOTOR CORTICAL PLASTICITY; NUCLEUS-ACCUMBENS SHELL; USE DISORDERS; LOW-FREQUENCY; CORTICOSPINAL EXCITABILITY;

D O I：

10.1016/j.alcohol.2018.05.011

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

Alcohol use disorders (AUDs) are one of the leading causes of mortality and morbidity worldwide. In spite of significant advances in understanding the neural underpinnings of AUDs, therapeutic options remain limited. Recent studies have highlighted the potential of repetitive transcranial magnetic stimulation (rTMS) as an innovative, safe, and cost-effective treatment for AUDs. Here, we summarize the fundamental principles of rTMS and its putative mechanisms of action via neurocircuitries related to alcohol addiction. We will also discuss advantages and limitations of rTMS, and argue that Hebbian plasticity and connectivity changes, as well as state-dependency, play a role in shaping some of the longterm effects of rTMS. Visual imaging studies will be linked to recent clinical pilot studies describing the effect of rTMS on alcohol craving and intake, pinpointing new advances, and highlighting conceptual gaps to be filled by future controlled studies. (C) 2018 Elsevier Inc. All rights reserved.

引用

页码：113 / 124

页数：12

共 188 条

[61] Transcranial magnetic stimulation in the treatment of substance addiction [J].