Aldosterone and the Kidney

被引：33
作者：
Fourkiotis, V. G. [1 ]
Hanslik, G. [1 ]
Hanusch, F. [1 ]
Lepenies, J. [2 ]
Quinkler, M. [1 ]
机构：
[1] Charite, Charite Campus Mitte, Dept Clin Endocrinol, D-10117 Berlin, Germany
[2] KfH Dialysis Ctr, Berlin, Germany
来源：
HORMONE AND METABOLIC RESEARCH | 2012年 / 44卷 / 03期
关键词：
aldosterone; chronic kidney disease; primary hyperaldosteronism; albuminuria; renal inflammation; DIETARY SALT REDUCTION; LOWER BLOOD-PRESSURE; MINERALOCORTICOID RECEPTOR BLOCKADE; CONVERTING ENZYME-INHIBITOR; INTIMA-MEDIA THICKNESS; ANGIOTENSIN-II; GLUCOCORTICOID-RECEPTOR; DIABETIC-NEPHROPATHY; SYNTHASE INHIBITION; OBSERVATIONAL DATA;
D O I：
10.1055/s-0031-1295461
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The mineralocorticoid aldosterone is a key regulator of blood pressure, fluid and electrolyte homeostasis, and acts via the mineralocorticoid receptor (MR). In recent years, an increasing number of studies revealed deleterious eff ects of aldosterone via its receptor. Especially in patients with primary hyperaldosteronism (PHA) a signifi cant higher risk of developing cardiovascular comorbidities and comortalities was reported. Also renal insuffi ciency is clearly increased in patients with PHA indicating a role of aldosterone and the MR in the pathogenesis of renal injury. It has been shown that aldosterone in combination with an elevated salt intake, leads to renal infl ammation, fi brosis, podocyte injury, and mesangial cell proliferation. This review focuses on the current knowledge of aldosterone eff ects in the kidney and highlights this topic from 2 perspectives: from clinical medicine and from experimental studies.
引用
收藏
页码：194 / 201
页数：8
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