2-amino-2-oxazolines, part 9:: Synthesis and pharmacological evaluation of N-phenyl-N′-[1-[3-(1-aryl-4-piperazinyl)propan-2-ol]]ureas

被引：0
|
作者：
Bosc, JJ [1 ]
Jarry, C [1 ]
机构：
[1] Univ Bordeaux 2, UFR Sci Pharmaceut, Chim Phys Lab, F-33076 Bordeaux, France
来源：
ARCHIV DER PHARMAZIE | 1998年 / 331卷 / 09期
关键词：
2-amino-2-oxazoline; 3-phenylcarbamoyl-2-iminooxazolidine; N-phenyl-N '-[l-[3-(1-aryl-4-piperazinyl)-propan-2-ol]]urea; antiallergic and analgesic activities;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
N-Phenyl-N'-[1-[3-(1-aryl-4-piperazinyl)propan-2-ol]]ureas (3) were synthesized from the 3-phenylcarbamoyl-5-[( 1-aryl-4-piperazinyl)methyl]-2-iminooxazolidines (1) via the corresponding 2-oxazolidinones (2). The prepared compounds were screened for their antiallergic and analgesic activities.
引用
收藏
页码：291 / 293
页数：3
相关论文
共 50 条
  • [21] 1-[2-(2-Methoxyphenylamino)ethylamino]-3-(naphthalene-1-yloxy)propan-2-ol May Be a Promising Anticancer Drug
    Nishizaki, Tomoyuki
    Kanno, Takeshi
    Tsuchiya, Ayako
    Kaku, Yoshiko
    Shimizu, Tadashi
    Tanaka, Akito
    MOLECULES, 2014, 19 (12) : 21462 - 21472
  • [22] SYNTHESIS, CRYSTAL-STRUCTURE AND PROPERTIES OF A CU(II) COMPLEX OF 1,3-(N-METHYLIMIDAZOLIMINE)PROPAN-2-OL
    DOMAN, TN
    RICHARDSON, JF
    BUCHANAN, RM
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1988, 195 : 537 - INOR
  • [23] Synthesis and structure of a binuclear Cu(II) complex of 1,3-bis [N,N-bis(2-picolyl)amino]propan-2-ol
    Marvey, Bassie B.
    Gultneh, Yilma
    Butcher, Ray
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2006, 7 (5-6): : 179 - 185
  • [24] Synthesis and positive inotropic evaluation of 1-(benzylamino)-3-(4,5-di-hydro[1,2,4]trizaolo[4,3-a]quinolin-7-yloxy)propan-2-ol derivatives
    Ting Ting Li~a Ling Zhang~b Zhe Shan Quan~a Hai Bo Zhu~(b
    Chinese Chemical Letters, 2009, 20 (02) : 175 - 177
  • [25] Synthesis and positive inotropic evaluation of 1-(benzylamino)-3-(4,5-di-hydro[1,2,4]trizaolo[4,3-a]quinolin-7-yloxy)propan-2-ol derivatives
    Li, Ting Ting
    Zhang, Ling
    Quan, Zhe Shan
    Zhu, Hai Bo
    Piao, Hu Ri
    CHINESE CHEMICAL LETTERS, 2009, 20 (02) : 175 - 177
  • [26] Antiarrhythmic activity in occlusion-reperfusion model of 1-(1H-indol-4-yloxy)-3-{[2-(2-methoxyphenoxy)ethyl]amino} propan-2-ol and its enantiomers
    Bednarski, Marek
    Otto, Monika
    Dudek, Magdalena
    Siwek, Agata
    Zygmunt, Malgorzata
    Knutelska, Joanna
    Nowinski, Leszek
    Groszek, Grazyna
    Sapa, Jacek
    CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2016, 43 (01): : 81 - 87
  • [27] Synthesis and in vitro antitumor activity of 1-(4-methylphenyl)-3-(morpholin-4-yl)-2-phenyl-1-R-propan-1-ol Hydrochlorides
    A. U. Isakhanyan
    G. A. Gevorgyan
    S. G. Chshmarityan
    L. E. Nersesyan
    A. S. Agaronyan
    I. S. Danielyan
    G. M. Stepanyan
    G. A. Panosyan
    Russian Journal of Organic Chemistry, 2016, 52 : 596 - 599
  • [28] Synthesis and in vitro antitumor activity of 1-(4-methylphenyl)-3-(morpholin-4-yl)-2-phenyl-1-R-propan-1-ol Hydrochlorides
    Isakhanyan, A. U.
    Gevorgyan, G. A.
    Chshmarityan, S. G.
    Nersesyan, L. E.
    Agaronyan, A. S.
    Danielyan, I. S.
    Stepanyan, G. M.
    Panosyan, G. A.
    RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2016, 52 (04) : 596 - 599
  • [29] (S,Z)-1-Chloro-3-[(3,4,5-trimethoxybenzylidene)amino]propan-2-ol
    Ren, Yun
    Qian, Shan
    Hai, Li
    Fan, Wei
    Wu, Yong
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2011, 67 : O245 - U1328
  • [30] SYNTHESIS, CRYSTAL-STRUCTURE AND PROPERTIES OF (1,3-(BIS(N-METHYLIMIDAZOLIMINE)-PROPAN-2-OL)CU(II)).PERCHLORATE
    DOMAN, TN
    RICHARDSON, JF
    ARAR, L
    BUCHANAN, RM
    INORGANICA CHIMICA ACTA, 1989, 159 (02) : 219 - 224
12345