Genetics of Substance Use Disorders

被引：14

作者：

Yu, Cassie ^{[1
]}

McClellan, Jon ^{[1
]}

机构：

[1] Univ Washington, Dept Psychiat, Box 356560, Seattle, WA 98195 USA

来源：

CHILD AND ADOLESCENT PSYCHIATRIC CLINICS OF NORTH AMERICA | 2016年 / 25卷 / 03期

关键词：

Genomics; Genome-wide association; Alcohol; Nicotine; Addiction; Alcohol dehydrogenase; Aldehyde dehydrogenase; Nicotinic acetylcholine receptors; GENOME-WIDE ASSOCIATION; ALCOHOL DEPENDENCE; CONSUMPTION; RECEPTORS; VARIANTS; GABRA2; ADOLESCENCE; CYP2A6;

D O I：

10.1016/j.chc.2016.02.002

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Substance abuse disorders have a strong genetic component. Genetic risk factors associated with alcohol abuse include common variants in genes coding for alcohol-metabolizing enzymes and gamma-aminobutyric acid A receptors. Functional missense mutations in ADH1B and ALDH2 are protective against alcohol dependence. Nicotine use disorders are associated with polymorphisms in a cluster of nicotinic acetylcholine receptors on chromosome 15q24, and mutations that reduce the enzymatic activity of CYP2A6. Genetic risk factors for other illicit drug use have not been well-studied. Most genetic vulnerability toward substance use disorders remains unexplained. Future research will benefit from advanced whole-genome sequencing technologies.

引用

页码：377 / +

页数：10

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