Natural Nanocontainer for the Controlled Delivery of Glycerol as a Moisturizing Agent

被引：66

作者：

Suh, Y. J. ^{[1
]}

Kil, D. S. ^{[1
]}

Chung, K. S. ^{[1
]}

Abdullayev, E. ^{[2
]}

Lvov, Y. M. ^{[2
]}

Mongayt, D. ^{[3
]}

机构：

[1] Korea Inst Geosci & Mineral Resources, Mineral Resources Res Div, Taejon 305350, South Korea

[2] Louisiana Tech Univ, Inst Micromfg, Ruston, LA 71272 USA

[3] Northeastern Univ, Ctr Pharmaceut Biotechnol & Nanomed, Boston, MA 02115 USA

来源：

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY | 2011年 / 11卷 / 01期

关键词：

Halloysite; Natural Nanotubes; Encapsulation; Glycerol; Cosmetics; HALLOYSITE CLAY NANOTUBES; DRUG-DELIVERY; CONTROLLED-RELEASE; SYSTEM;

D O I：

10.1166/jnn.2011.3194

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Natural halloysite nanotubes with a 15-nm internal lumen and a 50 nm outer diameter were investigated as a nanocontainer for the loading and extended release of glycerol for cosmetic applications. Cytotoxicity testing of the halloysite was conducted on 3T3 and MCF-7 cells, and the tubules showed no toxic effect on the cells for over 48 h. The capability of halloysite for loading glycerol was higher with the USA halloysite than with the New Zealand's, being similar to 20% and 2.3% by weight, respectively. The total elapsed time for releasing glycerol from the nanotubes exceeded 20 h. To further retard the glycerol release rate, the halloysite samples filled with glycerol were coated with several alternate layers of polyethyleneimine and polyacrylic acid. The release rate remained at the same level, however, probably due to the low molecular weight of the polyelectrolytes and the high solubility of glycerol in water.

引用

页码：661 / 665

页数：5

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