Lower brown adipose tissue activity is associated with non-alcoholic fatty liver disease but not changes in the gut microbiota

被引：48

作者：

Ahmed, Basma A. ^{[1
,2
]}

Ong, Frank J. ^{[1
,3
]}

Barra, Nicole G. ^{[1
,2
,4
]}

Blondin, Denis P. ^{[5
]}

Gunn, Elizabeth ^{[1
,3
]}

Oreskovich, Stephan M. ^{[1
,3
]}

Szamosi, Jake C. ^{[4
,6
]}

Syed, Saad A. ^{[2
]}

Hutchings, Emily K. ^{[1
,3
]}

Konyer, Norman B. ^{[7
]}

Singh, Nina P. ^{[8
]}

Yabut, Julian M. ^{[1
,9
]}

Desjardins, Eric M. ^{[1
,9
]}

Anhe, Fernando F. ^{[1
,2
,4
]}

Foley, Kevin P. ^{[1
,2
,4
]}

Holloway, Alison C. ^{[1
,10
]}

Noseworthy, Michael D. ^{[1
,7
,8
,11
,12
]}

Haman, Francois ^{[13
]}

Carpentier, Andre C. ^{[14
]}

Surette, Michael G. ^{[1
,2
,4
,15
]}

Schertzer, Jonathan D. ^{[1
,2
,4
]}

Punthakee, Zubin ^{[1
,3
,9
]}

Steinberg, Gregory R. ^{[1
,2
,9
]}

Morrison, Katherine M. ^{[1
,3
]}

机构：

[1] McMaster Univ, Ctr Metab Obes & Diabet Res, Hamilton, ON L8S 4L8, Canada

[2] McMaster Univ, Dept Biochem & Biomed Sci, Hamilton, ON L8S 4L8, Canada

[3] McMaster Univ, Dept Pediat, Hamilton, ON L8S 4L8, Canada

[4] McMaster Univ, Farncombe Family Digest Hlth Res Inst, Hamilton, ON L8S 4L8, Canada

[5] Univ Sherbrooke, Div Neurol, Dept Med, Ctr Rech CHUS,Fac Med & Hlth Sci, Sherbrooke, PQ J1K 2R1, Canada

[6] McMaster Univ, Dept Med, Farncombe Metagen Facil, Hamilton, ON L8S 4L8, Canada

[7] St Josephs Healthcare, Imaging Res Ctr, Hamilton, ON L8N 4A6, Canada

[8] McMaster Univ, Dept Radiol, Hamilton, ON L8S 4L8, Canada

[9] McMaster Univ, Div Endocrinol & Metab, Dept Med, Hamilton, ON L8S 4L8, Canada

[10] McMaster Univ, Dept Obstet & Gynecol, Hamilton, ON L8S 4L8, Canada

[11] McMaster Univ, Dept Elect & Comp Engn, Hamilton, ON L8S 4L8, Canada

[12] McMaster Univ, Sch Biomed Engn, Hamilton, ON 13FACULTY, Canada

[13] Univ Ottawa, Fac Hlth Sci, Ottawa, ON K1N 6N5, Canada

[14] Univ Sherbrooke, Dept Med, Ctr Rech CHUS, Div Endocrinol, Sherbrooke, PQ J1K 2R1, Canada

[15] McMaster Univ, Dept Med, Hamilton, ON L8S 4L8, Canada

来源：

CELL REPORTS MEDICINE | 2021年 / 2卷 / 09期

基金：

加拿大健康研究院;

关键词：

OXIDATIVE-METABOLISM; ENERGY HOMEOSTASIS; COLD-EXPOSURE; ADULT HUMANS; BEIGE FAT; BODY-FAT; OBESITY; DYSBIOSIS; SHIFT; IDENTIFICATION;

D O I：

10.1016/j.xcrm.2021.100397

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In rodents, lower brown adipose tissue (BAT) activity is associated with greater liver steatosis and changes in the gut microbiome. However, little is known about these relationships in humans. In adults (n = 60), we assessed hepatic fat and cold-stimulated BAT activity using magnetic resonance imaging and the gut micro biota with 16S sequencing. We transplanted gnotobiotic mice with feces from humans to assess the transferability of BAT activity through the microbiota. Individuals with NAFLD (n = 29) have lower BAT activity than those without, and BAT activity is inversely related to hepatic fat content. BAT activity is not related to the characteristics of the fecal microbiota and is not transmissible through fecal transplantation to mice. Thus, low BAT activity is associated with higher hepatic fat accumulation in human adults, but this does not appear to have been mediated through the gut microbiota.

引用

页数：19

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