The Role of Nrf2 in Skeletal Muscle on Exercise Capacity

被引：25

作者：

Kitaoka, Yu ^{[1
]}

机构：

[1] Kanagawa Univ, Dept Human Sci, Kanagawa Ku, 3-27-1 Rokkakubashi, Yokohama, Kanagawa 2218686, Japan

来源：

ANTIOXIDANTS | 2021年 / 10卷 / 11期

基金：

日本学术振兴会;

关键词：

Nrf2; oxidative stress; skeletal muscle; mitochondria; INDUCED OXIDATIVE STRESS; MITOCHONDRIAL BIOGENESIS; MUSCULAR-DYSTROPHY; ANTIOXIDANT; INTENSITY; CONTRACTILE; DEGRADATION; DISRUPTION; ACTIVATION; MECHANISMS;

D O I：

10.3390/antiox10111712

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nuclear factor erythroid 2-related factor 2 Nfe2l2 (Nrf2) is believed to play a crucial role in protecting cells against oxidative stress. In addition to its primary function of maintaining redox homeostasis, there is emerging evidence that Nrf2 is also involved in energy metabolism. In this review, we briefly discuss the role of Nrf2 in skeletal muscle metabolism from the perspective of exercise physiology. This article is part of a special issue "Mitochondrial Function, Reactive Oxygen/Nitrogen Species and Skeletal Muscle" edited by Hakan Westerblad and Takashi Yamada.

引用

页数：8

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