Advances on the Total Synthesis of Sesquiterpenoid Alkaloid Dendrobine

被引：4

作者：

Xiao, Jian ^{[1
]}

Peng, Yu ^{[1
,2
]}

Li, Wei-Dong Z. ^{[1
,2
]}

机构：

[1] Southwest Jiaotong Univ, Engn Res Ctr Biomimet Synth Nat Drugs Sichuan Pro, Sch Life Sci & Engn, Chengdu 610031, Peoples R China

[2] Yili Normal Univ, Key Lab Nat Prod Chem & Applicat Xinjiang, Yining 835000, Xinjiang, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 41卷 / 07期

基金：

中国国家自然科学基金;

关键词：

natural product; sesquiterpenoid alkaloid; dendrobine; total synthesis; picrotoxane; FORMAL TOTAL-SYNTHESIS; BIOSYNTHESIS; (-)-DENDROBINE; NOBILE; COPABORNEOL; SKELETON;

D O I：

10.6023/cjoc202101041

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Dendrobine is an important sesquiterpenoid alkaloid bearing the picrotoxane carbon skeleton isolated from the traditional Chinese medicine "Chin-Shih-Hu". Because of structural characteristics of fused polycyclic and seven contiguous stereocenters, and exhibiting analgesic, antipyretic activities, dendrobine has attracted a great deal of attentions from both synthetic organic chemists and medicinal chemists. Over the past 50 years, there has been a number of research reports on the pharmacological activities and chemical synthesis of dendrobine. This review summarizes the biosynthetic hypothesis and synthetic advances on dendrobine.

引用

页码：2636 / 2649

页数：14

共 52 条

[1]

[Anonymous], 1965, ACTA CHIM SINICA

[2]

[Anonymous], 1932, YAKUGAKU ZASSHI

[3] STEREOCHEMICAL ASPECTS OF SESQUITERPENE BIOSYNTHESIS [J].