Advances on the Total Synthesis of Sesquiterpenoid Alkaloid Dendrobine

被引：4
作者：
Xiao, Jian [1 ]
Peng, Yu [1 ,2 ]
Li, Wei-Dong Z. [1 ,2 ]
机构：
[1] Southwest Jiaotong Univ, Engn Res Ctr Biomimet Synth Nat Drugs Sichuan Pro, Sch Life Sci & Engn, Chengdu 610031, Peoples R China
[2] Yili Normal Univ, Key Lab Nat Prod Chem & Applicat Xinjiang, Yining 835000, Xinjiang, Peoples R China
来源：
CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 41卷 / 07期
基金：
中国国家自然科学基金;
关键词：
natural product; sesquiterpenoid alkaloid; dendrobine; total synthesis; picrotoxane; FORMAL TOTAL-SYNTHESIS; BIOSYNTHESIS; (-)-DENDROBINE; NOBILE; COPABORNEOL; SKELETON;
D O I：
10.6023/cjoc202101041
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Dendrobine is an important sesquiterpenoid alkaloid bearing the picrotoxane carbon skeleton isolated from the traditional Chinese medicine "Chin-Shih-Hu". Because of structural characteristics of fused polycyclic and seven contiguous stereocenters, and exhibiting analgesic, antipyretic activities, dendrobine has attracted a great deal of attentions from both synthetic organic chemists and medicinal chemists. Over the past 50 years, there has been a number of research reports on the pharmacological activities and chemical synthesis of dendrobine. This review summarizes the biosynthetic hypothesis and synthetic advances on dendrobine.
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页码：2636 / 2649
页数：14
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