Synthesis and Reactivity of [1,2,4]Triazolo-annelated Quinazolines

被引：28

作者：

Al-Salahi, Rashad A. ^{[1
]}

机构：

[1] King Saud Univ, Coll Pharm, Dept Pharmaceut Chem, Riyadh 11451, Saudi Arabia

来源：

MOLECULES | 2010年 / 15卷 / 10期

关键词：

triazolo[1,5-a]quinazolines; thionation; alkylation; chlorination; tetracyclic systems; H-1-ANTIHISTAMINIC AGENTS; DERIVATIVES; SYSTEMS; SERIES;

D O I：

10.3390/molecules15107016

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This paper reports the synthesis of phenyl-substituted 2-alkoxy(methylsulfanyl)-1,2,4-triazolo[1,5-a]quinazolines starting from N-cyanoimidocarbonates and substituted hydrazinobenzoic acids as building blocks. Thionation or chlorination of the inherent lactam moiety in the target compounds followed by treatment with multifunctional nucleophiles provided access to a variety of derivatives.

引用

页码：7016 / 7034

页数：19

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